Quantification of global transcription patterns in prokaryotes using spotted microarrays

Sidders, Ben; Withers, Mike; Kendall, Sharon L; Bacon, Joanna; Waddell, Simon J; Hinds, Jason; Golby, Paul; Movahedzadeh, Farahnaz; Cox, Robert A; Frita, Rosangela; ten Bokum, Annemieke MC; Wernisch, Lorenz; Stoker, Neil G

doi:10.1186/gb-2007-8-12-r265

Table 1 The 50 most highly expressed genes in vitro

From: Quantification of global transcription patterns in prokaryotes using spotted microarrays

	Rv	Name	ppm	Function [40]
1	Rv0009	ppiA	13,634	Protein translation and modification
2	Rv2527	Rv2527	10,020	Conserved hypotheticals
3	Rv3418c	groES	8,651	Chaperones-heat shock*
4	Rv3615c	Rv3615c	8,531	Conserved hypotheticals*
5	Rv0440	groEL2	8,300	Chaperones-heat shock*
6	Rv3258c	Rv3258c	5,430	Unknown*
7	Rv3616c	Rv3616c	5,370	Conserved hypotheticals*
8	Rv3477	PE31	5,138	PE subfamily
9	Rv2244	acpM	4,935	Synthesis of fatty and mycolic acids*
10	Rv0060	Rv0060	4,616	Unknown*
11	Rv3874	Rv3874	4,490	Conserved hypotheticals
12	Rv3875	esat6	4,115	SP, L, P and A^†
13	Rv3648c	cspA	4,101	Adaptations and atypical conditions*
14	Rv3053c	nrdH	3,934	2'-Deoxyribonucleotide metabolism
15	Rv3614c	Rv3614c	3,748	Conserved hypotheticals*
16	Rv1078	pra	3,582	Conserved hypotheticals
17	Rv2780	ald	3,577	Amino acids and amines
18	Rv1388	mIHF	3,499	Nucleoproteins*
19	Rv0003	recF	3,371	DNA R, R R and R^‡
20	Rv3786c	Rv3786c	3,164	Unknown
21	Rv1641	infC	2,993	Protein translation and modification*
22	Rv3269	Rv3269	2,778	Chaperones-heat shock
23	Rv1398c	Rv1398c	2,777	Conserved hypotheticals
24	Rv3407	Rv3407	2,732	Conserved hypotheticals
25	Rv2245	kasA	2,693	Synthesis of fatty and mycolic acids*
26	Rv0685	tuf	2,688	Protein translation and modification*
27	Rv2145c	wag31	2,652	SP, L, P and A*^†
28	Rv1306	atpF	2,620	ATP-proton motive force*
29	Rv0005	gyrB	2,466	DNA R, R R and R*^‡
30	Rv1305	atpE	2,455	ATP-proton motive force*
31	Rv0016c	pbpA	2,423	Murein sacculus and peptidoglycan
32	Rv1622c	cydB	2,418	Electron transport*
33	Rv3219	whiB1	2,373	Repressors-activators
34	Rv3583c	Rv3583c	2,345	Repressors-activators
35	Rv1980c	mpt64	2,254	SP, L, P and A^†
36	Rv1072	Rv1072	2,205	Other membrane proteins
37	Rv2457c	clpX	2,200	Proteins, peptides and glycopeptides*
38	Rv1958c	Rv1958c	2,195	Unknown
39	Rv3763	lpqH	2,180	Lipoproteins (lppA-lpr0)
40	Rv1872c	lldD2	2,149	Aerobic respiration
41	Rv3461c	rpmJ	2,133	Ribosomal protein synthesis*
42	Rv1361c	PPE19	2,127	PPE family
43	Rv0097	Rv0097	2,123	Conserved hypotheticals
44	Rv1971	Rv1971	2,034	Virulence
45	Rv3051c	nrdE	1,984	2'-Deoxyribonucleotide metabolism*
46	Rv2346c	Rv2346c	1,937	Conserved hypotheticals
47	Rv3679	Rv3679	1,931	Anions*
48	Rv1298	rpmE	1,883	Ribosomal protein synthesis*
49	Rv0108c	Rv0108c	1,837	Unknown
50	Rv2193	ctaE	1,793	Aerobic respiration*

*Essential genes (TraSH) [26,27]. ^†Surface polysaccharides, lipopolysaccharides, proteins and antigens. ^‡DNA replication, repair, recombination and restriction-modification.

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