From: Evolution of allostery in the cyclic nucleotide binding module
No. | Family name | NR/GOS count | Taxonomic origin | PBC consensus motif | Description |
---|---|---|---|---|---|
1 | PKA-Rsub | 301/0 | Eukaryote | GELALIYGTPRAATVVA | cAMP dependent regulatory subunit that activates PKA |
2 | PKG | 388/9 | Eukaryote | GELALLYNDPRTATVIA | cGMP activated proteins that are typically attached to a kinase domain |
3 | PKG-parasites | 362/11 | Eukaryote | GERALLYDEPRSATIKA | A distinct group of PKGs in parasites that are also attached to kinase domains |
4 | Other_eukaryotic | 940/201 | Eukaryote | GELALLYNAPRAATVVA | CNB domains from metazoans and plants. These are attached to various functional domains such as PKs, PAS domains, PP2C like phosphatases and phospholipases |
5 | Epac | 150/1 | Eukaryote | GQLALVNDAPRAATIVL | cAMP-dependent guanine nucleotide exchange factors. Typically attached to an amino-terminal DEP domain and a carboxy-terminal RasGEF domain |
6 | PDZ-GEF | 125/0 | Eukaryote | GVSPTMDKEYMKGVMRT | A distinct class of Epac's, also called Epac6, which contains a PDZ domain in between the CNB and RasGEF domain. Epac's of this class contain a non-canonical PBC |
7 | K-channel | 86/0 | Eukaryote | GEVGVLCYRPQLFTVRT | Potassium channels specific to plants. Most of them contain an Ankryin repeat carboxy-terminal to the CNB domain |
8 | LR_CC | 148/4 | Eukaryote | GEIGVLLDPPRTATVRA | CNB domains found in metazoans and fungi, usually occur in tandem like the PKA regulatory subunit and contain a carboxy-terminal F-box domain and leucine rich domain |
9 | HCN | 165/5 | Eukaryote | GEICLLTRGRRTASVRA | cGMP-gated cation channels. Mostly present in metazoans |
10 | K_HCN | 185/0 | Eukaryote | GENFWLYGTKSNADVRA | Potassium channels that contain a PAC motif (motif carboxy-terminal of PAS) amino-terminal of the trans-membrane segment. This subfamily also contains a non-canonical PBC |
11 | Channel_Tetrahym. | 218/44 | Eukaryote | GEEDFFSGQPRTFTAKC | Likely HCN channels from the single celled eukaryote Tetrahymena thermophila. This subfamily is quite distinct from the HCN channels in higher eukaryotes |
12 | Channel_protozoa | 587/41 | Eukaryote | GEISFFTGLPRTASARS | Other HCN channels in protozoans |
13 | Bact_Pyrredox | 38/70 | Prokaryote | GEMGLISGRRRGATVRA | Tandem CNB domains that are attached to an amino-terminal pyridine nucleotide-disulphide oxidoreductase domain |
14 | Channel_Bact | 99/79 | Prokaryote | GEIALLTGGPRTATVRA | Bacterial CNBs that are attached to mechanosensitive ion channels |
15 | HisK | 56/11 | Prokaryote | GELSLLTGGPRSATVRA | Bacterial CNBs that contain a HisK like ATPase, carboxy-terminal of the CNB domain |
16 | AAA_Atpase | 65/24 | Prokaryote | GEMALLSGQERKASVIA | A distinct sub-group containing AAA-ATPase domains attached to the CNB domain. Several members of this group contain an ABC-transporter like transmembrane region. The PBC arginine (Arg209) is quite variable within this family |
17 | NtcA | 108/104 | Prokaryote | GVLSLLTGSDRFYHAVA | Nitrogen responsive regulatory protein that contains a DNA binding domain (HTH) carboxy-terminal of the CNB domain |
18 | FixK | 43/0 | Prokaryote | G-ASLGGDHLFTAEA | Involved in nitrogen fixation and contains a HTH motif |
19 | FnR | 176/53 | Prokaryote | GEFDAIGSGHHPSFAQA | Transcriptional regulators that are implicated in oxygen sensing |
20 | ArcR | 29/0 | Prokaryote | PYGGLFTDDYYHESATA | Transcriptional regulator that is implicated in the aerobic arginase reaction. Arginine is used as a source of energy in bacteria |
21 | NnR | 28/0 | Prokaryote | GFARALQRGDYPGTATA | Transcriptional regulators that act on the nir and nor operons to achieve expression under aerobic conditions |
22 | CBS | 173/51 | Prokaryote | GERALLAGGPYSLTARA | This group contains tandem CBS domain located carboxy-terminal of the CNB domain |
23 | Other_bacterial | 1553/1486 | Prokaryote | GEMALLDGEPRSATVVA | Bacterial CNB domains that are attached to various functional domains such as CheY response regulators, Rhodanese homology domain, kinases and DNA binding domains |
24 | HTH_ICLR | 33/14 | Prokaryote | GEGAAFSEEPRSTTVVA | Transcriptional regulator that is implicated in the repression of the acetate operon (also known as glyoxylate bypass operon) in Escherichia coli and Salmonella typhimurium |
25 | HTH_GNTR | 85/52 | Prokaryote | GEASLFDGEPRSATVVA | Transcriptional regulator containing a HTH domain and implicated in the repression of the gluconate operon |
26 | Flp | 19/0 | Prokaryote | GEEALFGESNHANYCEA | Involved in the bacterial oxidative stress response |
27 | HTH_ARSR | 66/15 | Prokaryote | GEAALFSNGPYPATAIA | Functions as a transcriptional repressor of an arsenic resistance operon. Dissociates from DNA in the presence of the metal |
28 | HTH_CRP | 858/347 | Prokaryote | GEAALFDGGPRPATAVA | Transcriptional regulation of the crp operon |
29 | HTH_MARR | 143/20 | Prokaryote | GEMALLDGGPRSADAVA | Repressor of genes that activate the multiple antibiotic resistance and oxidative stress regulons |
30 | HTH_ASNC | 73/24 | Prokaryote | GEIALLDGGPRSATATA | An autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli |