Figure 6

MnSOD over-expression induces numerous cellular signaling pathways. Components of signaling pathways altered by MnSOD over-expression participate in both apoptosis and cytoprotection. Light or dark grey shading indicates genes that were altered only at the first time point (same chronological age) or at the second time point (same 'physiological age'), respectively. Pathways include: NF-κB, JNK, MAPK, Toll, Janus kinase/signal transducer and activator of transcription (JAK/STAT), IIS, cell-cycle (CC), and ubiquitin mediated degradation (Ub).