Figure 1

Patterns of transcript abundance in whole-blood samples from children with KD (cohort 1). Genes and samples were organized using hierarchical clustering; each row represents a single gene, and each column a single sample. Black indicates the median level of expression, red indicates greater expression than the median, green less expression, and gray missing data. Horizontal bars under the sample dendrogram at the top indicate samples from the same individual that cluster together; open circles represent samples obtained 1 or 2 days after IVIG treatment. Pretreatment acute KD samples are in yellow; early post-treatment subacute samples in light blue; late post-treatment convalescent samples in purple. Horizontal bars at the bottom of the figure indicate the sample groups mentioned in the text. A1 and A2 are clusters of acute samples; B is a cluster of subacute and convalescent samples. Vertical yellow bars (1 and 2) on the right mark the two gene clusters most strongly associated with the grouping of the pretreatment samples. The intrinsic score was graphed as a moving average of nine genes along the y-axis. The black vertical bars on the right lettered a, b, and c mark the three gene clusters with intrinsic scores more than 2 standard deviations away from the mean score of 0.742.