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Table 1 Mechanisms of ITS insertion

From: Contribution of telomerase RNA retrotranscription to DNA double-strand break repair during mammalian genome evolution

 

Number of loci

 

Rodents

Primates

Flanking sequence modification

Mouse

Rat

Total (%)

Human

Chimp

Both*

Total (%)

No modification

15

16

31 (23,2)

1

0

3

4 (16)

Deletion

27

38

65 (50)

2

2

9

13 (52)

Addition

10

12

22 (17)

1

1

2

4 (16)

   Random sequence

8

12

     

   TERC sequence†

2

0

     

Duplication

2

4

6 (4,6)

1

1

2

4 (16)

Addition and deletion

4

2

6 (4,6)

0

0

0

0 (0)

   Random sequence addition

1

2

     

   TERC sequence addition†

3

0

     

Total

58

72

130 (100)

5

4

16

25 (100)

  1. *These ITSs are present in both primate species and were inserted within repetitive elements. Their insertion mechanism was defined from the repetitive element consensus. †TERC sequence additions are present only in rodents.