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Table 1 Mechanisms of ITS insertion

From: Contribution of telomerase RNA retrotranscription to DNA double-strand break repair during mammalian genome evolution

  Number of loci
  Rodents Primates
Flanking sequence modification Mouse Rat Total (%) Human Chimp Both* Total (%)
No modification 15 16 31 (23,2) 1 0 3 4 (16)
Deletion 27 38 65 (50) 2 2 9 13 (52)
Addition 10 12 22 (17) 1 1 2 4 (16)
   Random sequence 8 12      
   TERC sequence 2 0      
Duplication 2 4 6 (4,6) 1 1 2 4 (16)
Addition and deletion 4 2 6 (4,6) 0 0 0 0 (0)
   Random sequence addition 1 2      
   TERC sequence addition 3 0      
Total 58 72 130 (100) 5 4 16 25 (100)
  1. *These ITSs are present in both primate species and were inserted within repetitive elements. Their insertion mechanism was defined from the repetitive element consensus. TERC sequence additions are present only in rodents.