Table 1 Predictability of 100 yeast gene deletion phenotypes

Caspofungin sensitive

0.996

20

18

[36]

Increased resistance to calcofluor white

0.982

10

10

[33]

Unipolar budding

0.941

10

10

[68]

CPY secretion (3)

0.937

46

44

[34]

Cell cycle arrest defective

0.930

8

8

[74]

UVC sensitive (high)

0.919

15

14

[75]

Sensitivity at 15 generations in galactose

0.908

17

14

[4]

CANR mutator (high)

0.904

18

18

[76]

Haploinsufficient in rich medium (YPD)

0.898

184

184

[77]

Cellular chitin level increased (3)

0.873

22

21

[33]

Bleomycin resistant (3)

0.871

5

4

[37]

Morphology: branched (diploid)

0.870

5

5

[4]

Sensitivity at 15 generations in 1.5 M sorbitol

0.867

6

4

[4]

Caspofungin resistant

0.866

8

8

[36]

Inviable (essential)

0.845

1100

1027

[4,30]

Shortened telomeres (3)

0.843

20

18

[32]

Sensitivity at 15 generations in minimal +his +leu +ura medium

0.843

77

70

[4]

MMS sensitive (3)

0.837

78

73

[78]

Cellular chitin level reduced (2)

0.835

17

17

[33]

Petite

0.833

179

166

[79]

Sensitivity at 5 generations in minimal +his +leu +ura medium

0.827

62

51

[4]

Long telomeres (3)

0.824

6

6

[32]

Decreased calcofluor white resistance

0.814

65

63

[77,80]

Growth defect on a fermentable carbon source

0.812

257

249

[81]

Transposon cDNA expression changed (high)

0.810

27

26

[82]

Morphology: clumpy (3)(diploid)

0.802

18

18

[4]

Gamma radiation sensitive (3)

0.793

31

31

[83]

Cell cycle arrest defective and defective shmoo

0.782

30

29

[74]

Sensitivity at 5 generations in galactose

0.781

11

10

[4]

Small (haploid)

0.778

215

192

[84]

Retrotransposition reduced

0.772

99

89

[82]

K1 killer toxin sensitive (40%)

0.770

72

72

[80]

Increased iron uptake

0.757

76

70

[35]

Growth defect on a non-fermentable carbon source

0.755

498

448

[81]

Gentamycin sensitive (high)

0.754

11

11

[85]

Proteasome inhibitor sens (high)

0.753

22

22

[86]

Reduced fitness in rich medium (YPD)

0.748

891

872

[77]

Mycophenolic acid sensitive

0.746

38

33

[87]

Axial budding

0.745

4

4

[68]

Morphology: elongate (3) (diploid)

0.739

77

73

[4]

Sporulation deficient

0.738

261

244

[88]

Random budding (high)

0.737

74

72

[68]

Large (haploid)

0.728

227

205

[84]

Reduced sporulation (3) (normal respiration)

0.722

136

119

[89]

Bleomycin sensitive (4)

0.721

58

55

[37]

Sensitivity at 5 generations in synthetic complete - lys medium

0.715

23

22

[4]

Decreased rapamycin resistance

0.707

272

256

[90]

Whi

0.706

19

19

[79]

Sensitivity at 5 generations in 1.5 M sorbitol

0.704

13

11

[4]

Decreased wortmannin resistance

0.703

89

85

[90]

Sensitivity at 20 generations in 1 M NaCl

0.703

63

59

[4]

K1 killer toxin resistant (40%)

0.698

19

18

[80]

Morphology: round (3) (diploid)

0.696

105

99

[4]

Uge

0.694

28

26

[79]

Sensitivity at 5 generations in synthetic complete - trp medium

0.694

48

45

[4]

Sensitivity at 5 generations in 1 M NaCl

0.693

60

56

[4]

Rapamycin resist (2)

0.692

26

26

[91]

Reduced iron uptake

0.688

5

5

[35]

Rate of growth loss of growth in 0.85 M NaCl

0.682

212

189

[92]

Sensitivity at 5 generations in medium of pH 8

0.677

102

93

[4]

Sensitivity at 15 generations in medium of pH 8

0.676

128

115

[4]

Morphology: small (3)(diploid)

0.672

79

69

[4]

Sensitivity at 15 generations in 10 uM nystatin

0.672

28

27

[4]

Morphology: large (3)(diploid)

0.669

88

80

[4]

Reduced glycogen storage (2)

0.666

44

41

[93]

Sensitivity at 5 generations in 10 uM nystatin

0.666

124

108

[4]

Increased rapamycin resistance

0.662

114

100

[90]

Morphology: unusual shmoo (haploid)

0.661

29

25

[74]

Morphology: polarized bud growth (haploid)

0.657

5

5

[74]

Wortmannin resistant (5)

0.656

25

23

[94]

Sensitivity at 5 generations in synthetic complete - thr medium

0.647

31

29

[5]

Enhanced glycogen storage (2)

0.645

61

55

[93]

Proteasome inhibitor resistant

0.642

7

6

[86]

Reduced spores per ascus

0.641

37

34

[89]

Rate of growth sensitivity in 0.85 M NaCl

0.629

209

191

[92]

Morphology: football (3) (diploid)

0.628

59

53

[5]

Germination deficient

0.627

158

147

[88]

Sporulation promoting

0.622

102

98

[88]

6AU sensitive (3)

0.618

28

26

[95]

Increased wortmannin resistance

0.617

80

75

[90]

Morphology: elongated (haploid)

0.603

110

101

[74]

Rapamycin sensitive (4)

0.597

20

20

[91]

Efficiency of growth sensitivity in 0.85 M NaCl

0.597

65

58

[92]

Decreased rapamycin resistance

0.597

8

7

[90]

Slow growth in YPD (16× below WT)

0.585

23

22

[4]

MPA sensitive (3)

0.563

24

22

[95]

Morphology: round (haploid)

0.552

13

11

[74]

Efficiency of growth resistance in 0.85 M NaCl

0.541

44

40

[92]

Sensitivity at 5 generations in synthetic complete medium

0.531

88

78

[5]

Morphology: large (haploid)

0.527

23

21

[74]

Adaptation time loss of growth in 0.85 M NaCl

0.526

103

91

[92]

Adaptation time sensitivity in 0.85 M NaCl

0.521

284

259

[92]

Decreased sensitivity to the anticancer drug, cisplatin

0.512

22

19

[96]

Morphology: chain (diploid)

0.485

5

5

[5]

Morphology: small (haploid)

0.480

94

89

[74]

Rate of growth resistance in 0.85 M NaCl

0.479

59

49

[92]

Morphology: clumped (haploid)

0.479

32

28

[74]

Adaptation time resistance in 0.85 M NaCl

0.465

69

60

[92]

Efficiency of growth loss of growth in 0.85 M NaCl

0.464

23

21

[92]

Morphology: pointed (haploid)

0.453

99

88

[74]