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Figure 6 | Genome Biology

Figure 6

From: Broad network-based predictability of Saccharomyces cerevisiaegene loss-of-function phenotypes

Figure 6

Lower probability linkages continue to improve predictive accuracy. The continued improvement of predictions, albeit with diminishing returns, is shown in a plot of the predictive accuracy (median area under the receiver operating characteristic [ROC] curve across the 100 phenotypes, calculated as in Figure 3) versus median network coverage of the 100 phenotype sets, as calculated for the top-ranked 20,000 (20 K), 40,000 (40 K), 60,000 (60 K), 80,000 (80 K), and 100,000 (100 K) linkages in YeastNet v. 2. This trend derives from the fact that all links in this network have at least a 60% probability of linking genes in the same pathway. The probabilistic nature of the network means that low confidence linkages are unlikely to undercut high confidence linkages during phenotype prediction because the links are weighted according to the strength of the evidence supporting them. Error bars indicate the first and third quartiles.

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