Figure 4
From: Broad network-based predictability of Saccharomyces cerevisiaegene loss-of-function phenotypes
A plot of seed set size versus predictability of the phenotype shows no significant correlation. Thus, there does not appear to be an intrinsic limitation for applying network-guided reverse genetics even when seed set size is small. Each filled circle indicates the prediction strength (area under the receiver operating characteristic [ROC] curve, as calculated in Figure 3) of one of the 100 loss-of-function phenotypes relative to the number of genes in that seed set.