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Table 2 Enriched GO biological process categories for self-synergistic E2F1 and NFAT from between-TFBS distance 20 bp to 90 bp

From: Prediction of synergistic transcription factors by function conservation

  E2F1 NFAT
Distance No. of genes Function categories No. of genes Function categories
D20 16 Cell cycle (0.07/0.09) 72 Homophilic cell adhesion (0.03/0.01)
D30 31 Sterol metabolism (0.004/0.004) 119 Homophilic cell adhesion (0.02/0.001)
     Immune response (0.06/0.003)
     Response to biotic stimulus (0.06/0.01)
     Regulation of T cell activation (0.04/0.02)
     Regulation of lymphocyte activation (0.07/0.002)
D40 49 Cell cycle (0.02/0.007) 166 Homophilic cell adhesion (0.04/0.006)
   Sterol metabolism (0.04/0.01)   Immune response (0.04/0.008)
   Nucleotide and nucleic acid metabolism (0.04/0.07)   Response to biotic stimulus (0.06/0.03)
     Regulation of T cell activation (0.07/0.03)
D50 64 Sterol metabolism (0.01/0.02) 205 Homophilic cell adhesion (0.01/0.0006)
   Cell cycle (0.005/0.02)   Immune response (0.08/0.03)
   Nucleotide and nucleic acid metabolism (0.01/0.02)   
D60 72 Cell cycle (0.002/0.009) 255 Immune response (0.03/0.002)
   Sterol metabolism (0.001/0.01)   Homophilic cell adhesion (0.03/0.002)
   Nucleotide and nucleic acid metabolism (0.008/0.02)   Response to biotic stimulus (0.09/0.01)
     Regulation of lymphocyte activation (0.06/0.02)
     Regulation of T cell activation (0.03/0.07)
     Cell-substrate adhesion (0.005/0.01)
D70 83 Cellular physiological process (0.002/0.02) 300 Homophilic cell adhesion (0.002/0.0005)
   Cell cycle (0.005/0.02)   Immune response (0.01/0.01)
   Nucleotide and nucleic acid metabolism (0.02/0.04)   Response to biotic stimulus (0.05/0.08)
   Sterol metabolism (0.002/0.003)   Regulation of lymphocyte activation (0.05/0.02)
     Cell-substrate adhesion (0.008/0.02
     Regulation of T cell activation (0.04/0.009)
D80 99 Nucleotide and nucleic acid metabolism (0.006/0.008) 341 Homophilic cell adhesion (0.0009/0.00001)
   Cell cycle (0.001/0.03)   Immune response (0.02/0.0004)
   Sterol metabolism (0.003/0.004)   Response to biotic stimulus (0.07/0.004)
   Cellular physiological process (0.001/0.01)   Regulation of lymphocyte activation (0.03/0.03)
     Cell-substrate adhesion (0.01/0.02)
D90 107 Nucleotide and nucleic acid metabolism (0.003/0.003) 392 Homophilic cell adhesion (0.0001/0.000001)
   Cell cycle (0.002/0.06)   Immune response (0.04/0.0008)
   Sterol metabolism (0.004/0.006)   Regulation of lymphocyte activation (0.05/0.04)
   Cellular physiological process (0.001/0.006)   Response to biotic stimulus (0.06/0.009)
     Cell-substrate adhesion (0.02/0.04)
  1. The number of overlapping orthologous human and mouse genes whose promoters have at least two TF binding sites within certain distance constraints (for example, D20 for a between-TFBS distance of 20 bp) is listed under "No. of genes". The statistical significances of commonly enriched biological process categories from both human and mouse genes are listed in parentheses (p value mouse/p value human).