Predictors of disease gene pairs in human. (a) Enrichments for disease gene pairs among eight predictors. An enrichment value of 1 reflects random performance (shown as 'all pairs', the left-most column). Predictors are arranged in order of increasing predictive power. Error bars indicate the hypergeometric standard deviation, which reflects the range of expected variation in the enrichment value. In the inset red bars are the same as in the main panel a and are in the same order (note the tenfold change in scale). Green bars indicate enrichments in the intersection of each dataset with Human Protein Reference Database (HPRD) interactions. Aside from HPRD intersected with itself or with all pairs, all but one dataset (high-throughput [HTP] interactions) exhibit a significant improvement in predictive power over HPRD interactions alone when intersected with HPRD; this indicates that these datasets are at least partially independent of HPRD. (b) Green bars are the same as in panel a (inset). Blue bars indicate the level of enrichment that would be expected by chance, if HPRD interactions were entirely independent of each dataset. Green bars significantly lower than the paired blue bar indicate a dataset that is not entirely independent of HPRD interactions. The three right-most blue bars are truncated for clarity; their enrichment values are written above each bar. Error bars indicate the hypergeometric standard deviation, which reflects the range of expected variation in the enrichment value.