From: Regulatory module network of basic/helix-loop-helix transcription factors in mouse brain
 |  |  |  |  | Regulators |  |  |  | ||
---|---|---|---|---|---|---|---|---|---|---|
No. | Module* | No. of target genes | Coherence (%)†| Significant gene annotations | R1 | R2 | R3 | E‡ | G§ | L¶ |
1 | Calcium-dependent cell-cell adhesion | 12 | 8 |  | Hey2 | Npas4 |  | √ | √ |  |
2 | Sialyltransferase activity | 6 | 17 |  | Neurod6 | Neurod1 |  | √ | √ |  |
3 | Transition metal ion binding | 4 | 50 |  | Neurod6 | Max |  | √ | √ |  |
4 | Monocyte differentiation | 2 | 50 |  | Tcf4 |  |  | √ | √ |  |
5 | Endoplasmic reticulum | 7 | 29 |  | Npas4 | Neurod6 |  | √ | √ |  |
6 | Protein heterodimerization activity | 2 | 50 | Â | Npas4 | Â | Â | Â | Â | Â |
7 | Eye development (sensu) vertebrata) | 6 | 33 |  | Npas4 | Heatr1 |  | √ | √ |  |
8 | Neurotransmitter metabolism | 7 | 14 |  | Hes5 | Npas4 |  | √ | √ |  |
9 | Anion channel activity | 1 | 100 |  | Npas4 | Neurod6 |  | √ | √ |  |
10 | Protein kinase activator activity | 3 | 33 |  | Hey2 | Neurod6 |  | √ | √ |  |
11 | Cation antiporter activity | 5 | 20 |  | Olig1 |  |  | √ | √ |  |
12 | Cell surface receptor linked signal transduction | 5 | 60 |  | Neurod6 | Max |  | √ | √ |  |
13 | Regulation of cell proliferation | 6 | 33 |  | Hes3 | Ascl1 |  | √ | √ |  |
14 | Stem cell division and DNA repair | 2 | 50 |  | Tcf4 |  |  | √ | √ |  |
15 | Cellular morphogenesis | 5 | 60 | P < 0.05 | Neurod6 | Hey2 |  | √ | √ |  |
16 | Sequence-specific DNA binding | 8 | 25 |  | Olig1 |  |  | √ | √ |  |
17 | Lipid biosynthesis | 12 | 25 | P < 0.05 | Neurod6 |  |  | √ | √ |  |
18 | Cytoskeletal regulatory protein binding | 6 | 17 |  | Ascl1 | Bhlhb5 |  | √ | √ |  |
19 | Negative regulation of metabolism | 18 | 17 |  | Olig1 | Neurod6 | Mitf | √ | √ | √ |
20 | Monovalent inorganic cation transporter activity | 4 | 25 |  | Nhlh2 |  |  | √ | √ |  |
21 | Intracellular non-membrane-bound organelle | 6 | 50 |  | Mitf | Npas4 |  | √ | √ | √ |
22 | Ribosome | 8 | 13 |  | Olig1 | Max |  | √ | √ | √ |
23 | Calcium ion binding | 9 | 33 |  | Hey2 |  |  | √ | √ | √ |
24 | Menstrual cycle | 7 | 14 |  | Max | Nhlh2 |  | √ | √ |  |
25 | Cytokine activity | 7 | 14 |  | Bhlhb5 | Myf6 |  | √ | √ | √ |
26 | Endosome | 12 | 8 |  | Olig1 | Neurod6 | Idb2 | √ | √ |  |
27 | Morphogenesis of embryonic epithelium | 5 | 20 |  | Hey2 | Neurod6 |  | √ | √ |  |
28 | Carboxylic ester hydrolase activity | 2 | 50 |  | Npas4 |  |  |  | √ |  |