From: Regulatory module network of basic/helix-loop-helix transcription factors in mouse brain
Regulators | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
No. | Module* | No. of target genes | Coherence (%)† | Significant gene annotations | R1 | R2 | R3 | E‡ | G§ | L¶ |
1 | Calcium-dependent cell-cell adhesion | 12 | 8 | Hey2 | Npas4 | √ | √ | |||
2 | Sialyltransferase activity | 6 | 17 | Neurod6 | Neurod1 | √ | √ | |||
3 | Transition metal ion binding | 4 | 50 | Neurod6 | Max | √ | √ | |||
4 | Monocyte differentiation | 2 | 50 | Tcf4 | √ | √ | ||||
5 | Endoplasmic reticulum | 7 | 29 | Npas4 | Neurod6 | √ | √ | |||
6 | Protein heterodimerization activity | 2 | 50 | Npas4 | ||||||
7 | Eye development (sensu) vertebrata) | 6 | 33 | Npas4 | Heatr1 | √ | √ | |||
8 | Neurotransmitter metabolism | 7 | 14 | Hes5 | Npas4 | √ | √ | |||
9 | Anion channel activity | 1 | 100 | Npas4 | Neurod6 | √ | √ | |||
10 | Protein kinase activator activity | 3 | 33 | Hey2 | Neurod6 | √ | √ | |||
11 | Cation antiporter activity | 5 | 20 | Olig1 | √ | √ | ||||
12 | Cell surface receptor linked signal transduction | 5 | 60 | Neurod6 | Max | √ | √ | |||
13 | Regulation of cell proliferation | 6 | 33 | Hes3 | Ascl1 | √ | √ | |||
14 | Stem cell division and DNA repair | 2 | 50 | Tcf4 | √ | √ | ||||
15 | Cellular morphogenesis | 5 | 60 | P < 0.05 | Neurod6 | Hey2 | √ | √ | ||
16 | Sequence-specific DNA binding | 8 | 25 | Olig1 | √ | √ | ||||
17 | Lipid biosynthesis | 12 | 25 | P < 0.05 | Neurod6 | √ | √ | |||
18 | Cytoskeletal regulatory protein binding | 6 | 17 | Ascl1 | Bhlhb5 | √ | √ | |||
19 | Negative regulation of metabolism | 18 | 17 | Olig1 | Neurod6 | Mitf | √ | √ | √ | |
20 | Monovalent inorganic cation transporter activity | 4 | 25 | Nhlh2 | √ | √ | ||||
21 | Intracellular non-membrane-bound organelle | 6 | 50 | Mitf | Npas4 | √ | √ | √ | ||
22 | Ribosome | 8 | 13 | Olig1 | Max | √ | √ | √ | ||
23 | Calcium ion binding | 9 | 33 | Hey2 | √ | √ | √ | |||
24 | Menstrual cycle | 7 | 14 | Max | Nhlh2 | √ | √ | |||
25 | Cytokine activity | 7 | 14 | Bhlhb5 | Myf6 | √ | √ | √ | ||
26 | Endosome | 12 | 8 | Olig1 | Neurod6 | Idb2 | √ | √ | ||
27 | Morphogenesis of embryonic epithelium | 5 | 20 | Hey2 | Neurod6 | √ | √ | |||
28 | Carboxylic ester hydrolase activity | 2 | 50 | Npas4 | √ |