CNS transcriptomes respond to caloric restriction in a region- and age-dependent manner. (a) CNS gene expression responses to CR. (b) Metabolic and signaling pathways in which genes were significantly affected by CR in all five CNS regions. Red, upregulated; blue, downregulated. (c) CNS AAGs reverted by CR. The percentage of AAGs reverted by CR is shown at the top of each bar. Note that the spinal cord exhibits a much larger percentage of upregulated AAGs that are reverted by CR compared to the other CNS regions. Gene lists are in Table S4a,c in Additional data file 1.