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Figure 4 | Genome Biology

Figure 4

From: Determinants of protein function revealed by combinatorial entropy optimization

Figure 4

The specificity residues in the complex of cell division protein kinase CDK2 and cyclin A. These predicted functional residues (red and blue) are predominantly on the front (left) rather than the back (right) of the functional complex and reflect a remarkable asymmetry indicative of protein-protein interactions on the front face. We propose a novel hypothetical functional cavity on the surface of the complex (yellow circle). Other colors: green, bound peptide; orange, phosphorylation sites Y15 and T160; and pink, ATP. Coordinates from data set 2cci of the Protein Data Bank.

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