Table 2 Functional tests of candidate genes
Line | Gene name | MET (SE) | p value | Human orthologue | Biological function |
|---|---|---|---|---|---|
Canton S B | Control | 5.4 (0.01) | NA | NA | NA |
BG02818 BG02327 | pipsqueak (psq) | 3.5 (0.08) 5.75 (0.22) | <0.0001 0.1776 | NA | Regulation of transcription, DNA-dependent |
BG02845 | Toll (Tl) | 3.6 (0.09) | <0.0001 | toll-like receptor 4* | Defense response, immune response, Toll signaling pathway |
BG02317 BG01705 BG02624 | CG9650 | 3.6 (0.10) 4.9 (0.18) 5.6 (0.16) | <0.0001 0.1118 0.6381 | B-cell lymphoma/leukemia 11A* | Regulation of transcription from RNA polymerase II promoter, nucleic acid binding |
BG02522 | CG32560 | 3.8 (0.15) | <0.0032 | DAB2 interacting protein* | Ras protein signal transduction, G-protein coupled receptor, MAPKKK cascade |
BG01371 | CG12505 | 4.3 (0.13) | 0.0012 | NA | Nucleic acid binding |
BG02560 | CG9674 | 4.3 (0.14) | 0.0042 | NA | Carbohydrate metabolism, amino acid biosynthesis |
BG02210 BG02523 | lamina ancestor (lama) | 4.6 (0.10) 5.7 (0.36) | 0.0014 0.6441 | NP_775813, novel gene | Unknown |
BG01037 | β ν integrin (βInt-ν) | 4.6 (0.13) | 0.0014 | NA | Signal transduction, defense response |
BG02812 BG02830 | Lipid storage droplet-2 (Lsd-2) | 4.7 (0.12) 5.52 (0.23) | 0.0083 0.7909 | Adipose differentiation-related protein | Lipid transport, sequestering of lipid |
BG02518 | CG8920 | 4.7 (0.11) | 0.0025 | Tudor domain containing protein 7 | Nucleic acid binding |
BG00987 | smell impaired 35A (smi35A) | 5.4 (0.14) | 0.9859 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 | Olfactory behavior, response to chemical stimulus, nervous system development |
BG01008 | CG11133 | 5.6 (0.09) | 0.6816 | NA | Unknown |
BG02207 BG2034 | lilliputian (lilli) | 5.8 (0.11) 6.0 (0.28) | 0.0905 0.1549 | Fragile X mental retardation 2 protein* | Regulation of transcription, DNA-dependent |
BG02114 BG01509 | CG30015 | 6.2 (0.17) 5.6 (0.31) | 0.0120 0.4924 | NA | Unknown |
BG02055 | little imaginal discs (lid) | 6.4 (0.11) | 0.0283 | Jumonji, AT rich interactive domain 1A | Regulation of transcription, DNA dependent |
BG01081 | Glutamate oxaloacetate transaminase 1 (Got1) | 6.5 (0.10) | 0.0048 | Glutamic-oxaloacetic transaminase 1 | Amino acid metabolism, biosynthesis |
BG01013 | Poly(ADP-ribose) glycohydrolase (Parg) | 6.5 (0.28) | 0.0137 | Poly(ADP-ribose) glycohydrolase* | Carbohydrate metabolism, glycolysis |
BG01389 | Laminin A (LanA) | 6.8 (0.15) | 0.0020 | laminin, alpha-5 | Proteolysis, signal transduction, central nervous system development |
BG02420 | CG5946 | 6.9 (0.15) | <0.0001 | Cytochrome b5 reductase 3* | Fatty acid desaturation, cholesterol metabolism |
BG01144 | CG17646 | 7.0 (0.16) | 0.0002 | NA | Lipid metabolism, nucleotide binding |
BG02731 BG02501 | longitudinals lacking (lola) | 7.1 (0.11) 5.8 (0.31) | <0.0001 0.5457 | Zinc finger and BTB domain containing protein 3 | Regulation of transcription from RNA polymerase II promoter, nervous system development |
BG02276 | CG7832 | 7.6 (0.13) | <0.0001 | NA | Protein binding |
BG02365 | Malic enzyme (Men) | 7.7 (0.24) | <0.0001 | Malic enzyme 1, NADP(+)-dependent | Malate metabolism, carbohydrate metabolism |
BG02180 | nuclear fallout (nuf) | 8.1 (0.18) | <0.0001 | RAB11 family interacting protein 4 | Protein binding, actin cytoskeleton reorganization |
BG01342 | Kinesin-73 (Khc-73) | 8.1 (0.21) | <0.0001 | kinesin family member 13A | Protein targeting, exocytosis |
BG02405 BG00525 | corto | 8.2 (0.21) 5.2 (0.21) | 0.0086 0.2390 | NA | Cell cycle, RNA polymerase II transcription factor activity, protein binding |
BG02128 | lethal (1) G0007 (l(1)G0007) | 8.3 (0.13) | <0.0001 | DEAH-box protein 38 | Nuclear mRNA splicing, via spliceosome; nucleic acid binding |
BG01672 | CG14591 | 8.7 (0.20) | <0.0001 | Transmembrane protein 164 | Unknown |
BG01989 | visgun (vsg) | 8.8 (0.19) | <0.0001 | Transmembrane protein 123* | Learning and/or memory, olfactory learning |
BG00291 | retinal degeneration B (rdgB) | 8.9 (0.19) | <0.0001 | phosphatidylinositol transfer protein, membrane-associated 2 | Lipid metabolism, sensory perception of smell, calcium ion transport |
BG01536 | Beadex (Bx) | 8.9 (0.19) | <0.0001 | LIM-only protein 1* | Nervous system development, regulation of transcription from RNA polymerase II promoter |
BG01733 | CG6175 | 9.0 (0.20) | <0.0001 | NA | Unknown |
BG01214 | sugarless (sgl) | 9.2 (0.20) | <0.0001 | UDP-glucose dehydrogenase | Lipid metabolism, cell surface receptor linked signal transduction |
BG02679 BG00990 | wing blister (wb) | 9.2 (0.15) 7.2 (0.13) | <0.0001 0.0093 | laminin, alpha 2* | Signal transduction |
BG01127 | muscleblind (mbl) | 9.6 (0.17) | <0.0001 | muscleblind-like 1, isoform b* | Peripheral nervous system development, response to stimulus, nucleic acid binding |