On the association between chromosomal rearrangements and genic evolution in humans and chimpanzees

Table 2 Analysis of factors known to affect evolutionary rates

	HSA X versus autosomes		Segmental duplications		Telomeres versus rest of genome		Centromeres versus rest of genome		HSA19
	Genes in autosomes	Genes in HSA X	Genes outside SDs	Genes within SDs	Genes outside telomeres	Genes within telomeres	Genes outside centromeres	Genes within centromeres	Genes outside HSA19	Genes within HSA19
N	11,691	434	8,431	3,260	6,627	1,804	6,165	462	5,804	361
K_I	0.0127	0.0094	0.0127	0.0127	0.0121	0.0149	0.0121	0.0118	0.0121	0.0132
		< 0.001		0.982		< 0.001		< 0.001		< 0.001
K_A	0.0032	0.0029	0.0031	0.0033	0.0029	0.0040	0.0029	0.0030	0.0029	0.0032
		0.129		0.048		< 0.001		0.687		0.114
K_S	0.0145	0.0088	0.0147	0.0138	0.0129	0.0213	0.0130	0.0118	0.0127	0.0176
		< 0.001		0.002		< 0.001		0.039		< 0.001
K_A/K_I	0.2459	0.2987	0.2434	0.2525	0.2370	0.2669	0.2364	0.2453	0.2360	0.2422
		0.002		0.161		< 0.001		0.537		0.671

Average divergence measures are compared between genes within and outside genomic regions previously shown to be affected by processes influencing divergence rates. See text for details.

ISSN: 1474-760X