Breaking the waves: improved detection of copy number variation from microarray-based comparative genomic hybridization

Table 1 Performance of the CNVfinder algorithm using validated data before wave correction

		Calls
Status	Number of regions	A	B	C	D	E
Unvalidated	25	4	4	3	0	0
Validated	112	68	70	65	47	35
Total	137	72	74	68	47	35
False discovery rate		6	5	4	0	0
Sensitivity (confidence interval)		61 (51, 70)	62 (53, 72)	58 (48, 67)	42 (33, 52)	31 (23, 41)
Specificity (confidence interval)		84 (66, 95)	84 (66, 95)	88 (71, 97)	100 (90, 100)	100 (90, 100)

The number of regions called in five replicate experiments (A to E, ranked by standard deviation) using CNVfinder before wave correction. The false discovery rate, sensitivity and specificity are quoted as percentages and the confidence intervals quoted are the 95% intervals.

ISSN: 1474-760X