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Table 6 The number of regulated genes in response to different concentrations of toxicants

From: Transcriptional profiling reveals barcode-like toxicogenomic responses in the zebrafish embryo

Toxicants

Stage

Concentration

Number of regulated genes

4CA

120 hpf

50 mg/l

201

  

25 mg/l

2

  

5 mg/l

0

Cd

120 hpf

5 mg/l

475

  

2.5 mg/l

102

  

0.5 mg/l

57

DDT

120 hpf

15 mg/l

25

  

1.5 mg/l

0

  

0.15 mg/l

0

TCDD

120 hpf

500 ng/l

34

  

250 ng/l

34

  

50 ng/l

4

VA

120 hpf

50 mg/l

335

  

25 mg/l

1

  

5 mg/l

4

MeHg

120 hpf

60 μg/l

417

  

30 μg/l

20

  

6 μg/l

9

  1. The fold change was equal to or greater than 1.5 and padj < 0.025. Note that for reasons of increased sensitivity we used a lower fold-change cutoff in this experiment compared with that in Figure 2b, which explains the higher number of regulated genes in this set of experiments.