Table 1 Core apoptosis domains in several completed animal genomes
From: Surprising complexity of the ancestral apoptosis network
Classification | Species | NB-ARC domain | Bcl-2 (multi-motif) | Caspase | CARD domain | Death domain (DD) | Death effector domain (DED) |
|---|---|---|---|---|---|---|---|
Vertebrata | H. sapiens (human) | 1 (1) | 17 (12) | 11 (11) | 23 (22) | 31 (29) | 8 (8) |
| Â | M. musculus (mouse) | 1 (1) | 15 (11) | 9 (9) | 23 (21) | 28 (25) | 6 (6) |
| Â | C. familiaris (dog) | 1 (1) | 14 (10) | 14 (14) | 20 (19) | 37 (33) | 5 (5) |
| Â | G. gallus (chicken) | 1 (1) | 13 (7) | 13 (13) | 13 (12) | 30 (24) | 6 (6) |
| Â | X. tropicalis (western clawed frog) | 1 (1) | 14 (11) | 13 (13) | 28 (28) | 31 (28) | 5 (5) |
| Â | B. rerio (zebrafish) | 1 (1) | 16 (13) | 21 (21) | 30 (28) | 35 (33) | 5 (5) |
| Â | F. rubripes (Japanese pufferfish) | 1 (1) | 15 (12) | 13 (13) | 15 (14) | 32 (28) | 6 (6) |
| Â | T. nigroviridis (green pufferfish) | 1 (1) | 13 (11) | 14 (14) | 14 (12) | 33 (30) | 5 (4) |
Cephalochordata | B. floridae (amphioxus) | 16 (16) | 7 (7) | 53 (53) | 84 (84) | 139 (136) | 57 (57) |
Urochordata | C. intestinalis (sea squirt) | 0* | 1 (1) | 11 (11) | 2 (2) | 5 (4) | 2 (2) |
Echinodermata | S. purpuratus (purple sea urchin) | 5 (5) | 8 (8) | 42 (42) | 12 (10) | 87 (82) | 3 (3) |
Ecdysozoa | D. melanogaster (fruit fly) | 1 (1) | 2 (2) | 7 (7) | 1 (0) | 5 (5) | 0 |
| Â | C. elegans | 1 (1) | 1 (1) | 5 (5) | 1 (1) | 2 (2) | 0 |
Cnidaria | N. vectensis (starlet sea anemone) | 4 (4) | 11 (11) | 10 (10) | 8 (8) | 5 (5) | 9 (9) |