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Table 7 Effect of Hfe disruption on plasma lipid profiles

From: Gene expression profiling of Hfe-/-liver and duodenum in mouse strains with differing susceptibilities to iron loading: identification of transcriptional regulatory targets of Hfe and potential hemochromatosis modifiers

 

C57BL/6 strain

DBA/2 strain

 

Hfe -/-

Hfe +/+

P

Hfe -/-

Hfe +/+

P

Total cholesterol (mg/ml)

0.93 ± 0.24

1.07 ± 0.05

0.28

1.46 ± 0.25

1.17 ± 0.13

0.04

HDL-cholesterol (mg/ml)

0.71 ± 0.18

0.86 ± 0.05

0.16

1.14 ± 0.11

0.97 ± 0.08

0.02

  1. Hfe-/- and Hfe+/+ mice (five males per group) were killed at age 7 weeks. Blood was removed and plasma lipid levels were determined by chromatography. Results are expressed as mean ± standard deviation in each group. P values for comparisons of plasma lipid levels between Hfe-/- and Hfe+/+ mice of each strain were obtained by Student's t-test. HDL, high-density lipoprotein.
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Genome Biology

ISSN: 1474-760X

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