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Table 6 Genes differentially expressed between wild-type strains or regulated by Hfe deficiency, located within the chromosomal regions containing Hfe-modifiers, and with evidence for cis regulation

From: Gene expression profiling of Hfe-/-liver and duodenum in mouse strains with differing susceptibilities to iron loading: identification of transcriptional regulatory targets of Hfe and potential hemochromatosis modifiers

Gene name Chromosome Position (Mb) Type Position of linkage peak (Mb) for cis regulator Max LRS for cis regulator
Clca2 3 144.73 D 144.70 to 144.94 46.7
Lphn2 3 148.87 S 149.36 to 151.27 15.5
Uble1a 7 15.49 S 15.19 to 15.53 51.53
Ckap1 7 29.93 S 29.49 to 30.12 53.8
Hamp1/Hamp2 7 30.63 L, S 30.43 to 34.11 18.9
Fxyd5 7 30.74 D 34.41 to 34.62 15.2
Gpsn2 8 86.46 S 83.77 to 85.83 15.2
Ddx39 8 86.61 L 86.07 to 88.74 12.7
2410018C20Rik 8 87.14 S 86.07 to 88.74 20.6
Ier2 8 87.55 L 86.07 to 88.74 15.9
Gadd45gip1 8 87.72 S 86.07 to 88.74 116.4
Prdx2 8 87.86 S 83.77 to 85.83 36.1
Pttg1 11 43.26 S 42.87 to 44.25 68.9
5730409G07Rik 11 45.79 S 42.21 to 46.06 16.4
2900006B13Rik 11 51.43 L, S 50.95 to 53.90 38.9
Tnip1 11 54.75 S 50.95 to 53.90 60.6
Sparc 11 55.24 S 55.24 to 55.92 26.1
Guk1 11 59.00 S 58.93 to 59.04 50.8
Sat2 11 69.44 S 69.42 to 70.27 133.2
Mpdu1 11 69.47 S 72.49 to 72.98 43.3
Asgr2 11 69.91 S 69.42 to 70.27 69.9
Rabep1 11 70.66 L 73.93 to 75.08 18.3
Txnl5 11 72.02 S 67.96 to 68.74 11.1
Pafah1b1 11 74.49 L, S 75.29 to 76.41 14.5
Crk 11 75.50 L 76.76 to 76.83 10.5
Ccl9 11 83.39 L, S 88.48 to 89.36 36.9
Bcas3 11 85.17 S 89.57 to 89.92 12.2
Dhx40 11 86.59 S 83.52 to 88.25 36.8
Scpep1 11 88.74 L, S 83.52 to 88.25 39.2
9030617O03Rik 12 101.18 S 100.97 to 102.71 51.5
  1. The Chromosome and Position columns indicate, respectively, the chromosome number and position (in megabases [Mb]) within one of the five Hfe-modifier intervals of the gene with expression variation. In the Type column, S indicates that expression differed between wild-type strains, D that expression was modulated by Hfe deficiency in duodenum, and L that expression was modulated by Hfe deficiency in liver. Max LRS indicates the maximum likelihood ratio statistic in favor of the cis regulator. Position of linkage peak for cis regulator and maximum LRS were retrieved from the WebQTL interface.