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Table 6 Genes differentially expressed between wild-type strains or regulated by Hfe deficiency, located within the chromosomal regions containing Hfe-modifiers, and with evidence for cis regulation

From: Gene expression profiling of Hfe-/-liver and duodenum in mouse strains with differing susceptibilities to iron loading: identification of transcriptional regulatory targets of Hfe and potential hemochromatosis modifiers

Gene name

Chromosome

Position (Mb)

Type

Position of linkage peak (Mb) for cis regulator

Max LRS for cis regulator

Clca2

3

144.73

D

144.70 to 144.94

46.7

Lphn2

3

148.87

S

149.36 to 151.27

15.5

Uble1a

7

15.49

S

15.19 to 15.53

51.53

Ckap1

7

29.93

S

29.49 to 30.12

53.8

Hamp1/Hamp2

7

30.63

L, S

30.43 to 34.11

18.9

Fxyd5

7

30.74

D

34.41 to 34.62

15.2

Gpsn2

8

86.46

S

83.77 to 85.83

15.2

Ddx39

8

86.61

L

86.07 to 88.74

12.7

2410018C20Rik

8

87.14

S

86.07 to 88.74

20.6

Ier2

8

87.55

L

86.07 to 88.74

15.9

Gadd45gip1

8

87.72

S

86.07 to 88.74

116.4

Prdx2

8

87.86

S

83.77 to 85.83

36.1

Pttg1

11

43.26

S

42.87 to 44.25

68.9

5730409G07Rik

11

45.79

S

42.21 to 46.06

16.4

2900006B13Rik

11

51.43

L, S

50.95 to 53.90

38.9

Tnip1

11

54.75

S

50.95 to 53.90

60.6

Sparc

11

55.24

S

55.24 to 55.92

26.1

Guk1

11

59.00

S

58.93 to 59.04

50.8

Sat2

11

69.44

S

69.42 to 70.27

133.2

Mpdu1

11

69.47

S

72.49 to 72.98

43.3

Asgr2

11

69.91

S

69.42 to 70.27

69.9

Rabep1

11

70.66

L

73.93 to 75.08

18.3

Txnl5

11

72.02

S

67.96 to 68.74

11.1

Pafah1b1

11

74.49

L, S

75.29 to 76.41

14.5

Crk

11

75.50

L

76.76 to 76.83

10.5

Ccl9

11

83.39

L, S

88.48 to 89.36

36.9

Bcas3

11

85.17

S

89.57 to 89.92

12.2

Dhx40

11

86.59

S

83.52 to 88.25

36.8

Scpep1

11

88.74

L, S

83.52 to 88.25

39.2

9030617O03Rik

12

101.18

S

100.97 to 102.71

51.5

  1. The Chromosome and Position columns indicate, respectively, the chromosome number and position (in megabases [Mb]) within one of the five Hfe-modifier intervals of the gene with expression variation. In the Type column, S indicates that expression differed between wild-type strains, D that expression was modulated by Hfe deficiency in duodenum, and L that expression was modulated by Hfe deficiency in liver. Max LRS indicates the maximum likelihood ratio statistic in favor of the cis regulator. Position of linkage peak for cis regulator and maximum LRS were retrieved from the WebQTL interface.