Table 3 Main genes regulated by Hfe deficiency in liver and pertaining to the enriched functional categories fatty acid β-oxidation and cholesterol metabolism
Gene | Protein | S-score | ||
|---|---|---|---|---|
D2 KO versus WT | B6 KO versus WT | D2 WT versus B6 WT | ||
Fatty acid β-oxidation | ||||
Cpt1a | Carnitine palmitoyl transferase 1a | -2.95 | -1.94 | NS |
Cpt2 | Carnitine palmitoyl transferase 2 | -2.59 | NS | NS |
Acadm | Acyl-CoA dehydrogenase, medium chain | -2.97 | -1.80 | NS |
Acadl | Acyl-CoA dehydrogenase, long chain | -3.00 | NS | NS |
Acadvl | Acyl-CaA dehydrogenase, very long chain | -2.40 | NS | NS |
Ehhadh | Enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase | -2.30 | NS | NS |
Hadha | Tripartite protein, alpha subunit | -2.08 | -1.58 | NS |
Hadhb | Tripartite protein, beta subunit | -2.96 | -1.90 | NS |
Hadh2 | Hydroxyacyl-CoA dehydrogenase type II | NS | -4.05 | -4.61 |
Acox1 | Acyl-CoA oxydase 1, palmitoyl (peroxisomal) | -2.10 | -1.63 | -4.27 |
Cyp4a10 | Cytochrome P450 4A10 | -6.76 | -2.46 | NS |
Cpy4a14 | Cytochrome P450 4A14 | -9.21 | -3.09 | NS |
TCA cycle | ||||
Aco2 | Aconitase 2, mitochondrial | -2.14 | -1.82 | NS |
Idh2 | Isocitrate dehydrogenase 2, mitochondrial | -2.09 | NS | NS |
Cholesterol catabolism | ||||
Cyp7a1 | Cholesterol 7α-hydroxylase | -3.15 | NS | NS |
Cyp39a1 | Oxysterol 7α-hydroxylase | -2.60 | NS | NS |