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Table 3 Main genes regulated by Hfe deficiency in liver and pertaining to the enriched functional categories fatty acid β-oxidation and cholesterol metabolism

From: Gene expression profiling of Hfe-/-liver and duodenum in mouse strains with differing susceptibilities to iron loading: identification of transcriptional regulatory targets of Hfe and potential hemochromatosis modifiers

Gene Protein S-score
   D2 KO versus WT B6 KO versus WT D2 WT versus B6 WT
Fatty acid β-oxidation
   Cpt1a Carnitine palmitoyl transferase 1a -2.95 -1.94 NS
   Cpt2 Carnitine palmitoyl transferase 2 -2.59 NS NS
   Acadm Acyl-CoA dehydrogenase, medium chain -2.97 -1.80 NS
   Acadl Acyl-CoA dehydrogenase, long chain -3.00 NS NS
   Acadvl Acyl-CaA dehydrogenase, very long chain -2.40 NS NS
   Ehhadh Enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase -2.30 NS NS
   Hadha Tripartite protein, alpha subunit -2.08 -1.58 NS
   Hadhb Tripartite protein, beta subunit -2.96 -1.90 NS
   Hadh2 Hydroxyacyl-CoA dehydrogenase type II NS -4.05 -4.61
   Acox1 Acyl-CoA oxydase 1, palmitoyl (peroxisomal) -2.10 -1.63 -4.27
   Cyp4a10 Cytochrome P450 4A10 -6.76 -2.46 NS
   Cpy4a14 Cytochrome P450 4A14 -9.21 -3.09 NS
TCA cycle
   Aco2 Aconitase 2, mitochondrial -2.14 -1.82 NS
   Idh2 Isocitrate dehydrogenase 2, mitochondrial -2.09 NS NS
Cholesterol catabolism
   Cyp7a1 Cholesterol 7α-hydroxylase -3.15 NS NS
   Cyp39a1 Oxysterol 7α-hydroxylase -2.60 NS NS
  1. S-scores were obtained as described in Material and methods and are proportional to fold changes. Negative S-scores indicate that the genes are more highly expressed in wild-type (WT) than in knockout (KO) mice, or in WT B6 than in WT D2 mice. Variations in the expression of genes involved in the tricarboxylic acid (TCA) cycle are provided for information. CoA, coenzyme A; NS, not significant.