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Table 2 Main genes regulated by Hfe deficiency in liver and pertaining to enriched functional categories related to response to oxidative stress

From: Gene expression profiling of Hfe-/-liver and duodenum in mouse strains with differing susceptibilities to iron loading: identification of transcriptional regulatory targets of Hfe and potential hemochromatosis modifiers

Gene Protein S-score
   D2 KO versus WT B6 KO versus WT D2 WT versus B6 WT
Glutathione metabolism pathway
   Gclc Glutamate-cysteine ligase, catalytic subunit 3.68 4.74 3.24
   Gclm Glutamate-cysteine ligase, modifier subunit NS 4.11 NS
   Gss Glutathione synthetase NS 2.15 NS
   Gsta2 Glutathione S-transferase alpha2 8.83 9.10 NS
   Gsta3 Glutathione S-transferase alpha3 2.44 2.24 NS
   Gsta4 Glutathione S-transferase alpha4 4.64 5.99 4.35
   Gstm1 Glutathione S-transferase mu1 NS 2.65 NS
   Gstm3 Glutathione S-transferase mu3 3.04 4.04 2.56
   Gstm6 Glutathione S-transferase mu6 3.36 2.26 NS
UDP glucuronosyltransferase activity
   Ugt2b1 UDP glucuronosyltransferase 2B1 3.72 NS NS
   Ugt2b5 UDP glucuronosyltransferase 2B5 2.56 3.91 NS
   Ugt2b34 UDP glucuronosyltransferase 2B34 NS 2.25 NS
   Ugt2b35 UDP glucuronosyltransferase 2B35 2.56 3.91 NS
   Ugt2b36 UDP glucuronosyltransferase 2B36 4.66 NS -4.89
Mono-oxygenase activity
   Cyp1a2 Cytochrome P450 1A2 3.14 2.60 3.49
   Cyp2c29 Cytochrome P450 2C29 NS 2.79 4.84
   Cup2c44 Cytochrome P450 2C44 3.07 NS -5.89
   Cyp2c55 Cytochrome P450 2C55 3.94 6.22 4.43
   Cyp2c70 Cytochrome P450 2C70 5.55 4.70 4.17
   Cyp2j6 Cytochrome P450 2J6 2.70 NS NS
   Cyp2j9 Cytochrome P450 2J9 NSD 2.91 2.14
   Cyp2u1 Cytochrome P450 2U1 3.50 NS NS
   Fmo5 Flavin mono-oxygenase 5 2.12 NS NS
Iron ion binding
   Ftl1 Ferritin light chain 1 1.70 2.24 NS
   Slc40a1 Ferroportin 3.18 4.89 3.94
   Hmox1 Heme oxygenase 1 5.27 2.40 -3.66
   Blvrb Biliverdin reductase (for information) 2.50 3.06 NS
   Vnn1 Vanin 1 (for information) -4.27 -2.73 2.69
  1. S-scores were obtained as described in Materials and methods and are proportional to fold changes. Positive S-scores indicate that the genes are more highly expressed in knockout (KO) than in wild-type (WT) mice, or in WT D2 than in WT B6 mice. NS, not significant; UDP, Uridine 5'-diphospho.