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Figure 1 | Genome Biology

Figure 1

From: Harnessing naturally randomized transcription to infer regulatory relationships among genes

Figure 1

An illustration of the properties required to infer the causal relationship LT i T j . (a) All gene expression traits are normalized to follow a N(0,1) distribution. By the causality equivalence theorem, in order to conclude that LT i T j , it must be the case that (b) T i is linked to L, where the mean expression among segregants with allele at L inherited from the BY parental strain is different from the mean expression among segregants with allele at L inherited from the RM parental strain; (c) T j is also linked to L; and (d) the expression of T j given T i is no longer linked to L. Trigger is an algorithm to estimate the probability that all three conditions (shown in panels b to d) hold simultaneously.

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