Table 2 Hotspots of gain and amplification
CytoBand | Start | Length | Gains (T) | nAMP (T) | Gains (CL) | nAMP (CL) | Genes |
|---|---|---|---|---|---|---|---|
1q21.1 | 144.22 | 1.65 | 0.49 | 10 | 0.37 | 0 | RBM8A, POLR3C, ZNF364 |
1q21.3-1q22 | 153.29 | 0.09 | 0.51 | 8 | 0.39 | 0 | EFNA4, MUC1 |
1q23.2 | 157.95 | 0.32 | 0.53 | 10 | 0.39 | 1 | DUSP23, IGSF9 |
1q23.3 | 159.23 | <0.01 | 0.55 | 12 | 0.43 | 1 | F11R |
1q42.13-1q42.2 | 226.95 | 2.59 | 0.57 | 12 | 0.45 | 0 | SPHAR, NUP133, GALNT2 |
1q43-1q44 | 240.32 | 4.75 | 0.58 | 11 | 0.45 | 0 | SDCCAG8, ADSS, FAM36A |
6q21 | 107.12 | <0.01 | 0.11 | 5 | 0.02 | 0 | AIM1 |
6q21 | 107.14 | 0.2 | 0.11 | 4 | 0.02 | 0 | RTN4IP1, QRSL1 |
8p12 | 37.82 | <0.01 | 0.32 | 16 | 0.24 | 4 | GPR124, BRF2 |
8p12 | 38.04 | 0.1 | 0.32 | 17 | 0.22 | 3 | ASH2L, LSM1 |
8p12 | 38.24 | 0.06 | 0.32 | 18 | 0.24 | 3 | WHSC1L1 |
8q21.13 | 82.73 | 0.14 | 0.47 | 13 | 0.37 | 1 | ZFAND1, CHMP4C |
8q21.3 | 87.54 | 0.48 | 0.49 | 15 | 0.39 | 1 | FAM82B, CPNE3 |
8q22.3 | 102.57 | 1.37 | 0.54 | 17 | 0.51 | 1 | GRHL2, RRM2B, EDD1*, AZIN1* |
8q22.3 | 104.52 | <0.01 | 0.54 | 15 | 0.51 | 1 | WDSOF1* |
8q24.11 | 118.02 | 0.58 | 0.54 | 23 | 0.61 | 4 | THRAP6* |
8q24.12 | 120.81 | 0.1 | 0.53 | 23 | 0.57 | 3 | DCC1* |
8q24.13 | 124.90 | 1.14 | 0.53 | 22 | 0.65 | 3 | TRMT12*, RNF139*, NDUFB9* |
8q24.13 | 126.06 | 0.28 | 0.53 | 23 | 0.65 | 4 | SQLE*, KIAA0196* |
8q24.3 | 144.53 | 0.09 | 0.40 | 12 | 0.39 | 0 | RHPN1, ZC3H3 |
9p22.3-9p22.1 | 16.40 | 2.65 | 0.11 | 1 | 0.12 | 1 | C9orf39, FAM29A |
10p14 | 12.20 | 0.05 | 0.20 | 2 | 0.18 | 0 | NUDT5, SEC61A2 |
10p13 | 12.33 | 2.66 | 0.20 | 3 | 0.18 | 0 | OPTN, FAM107B, SUV39H2 |
11q13.3 | 69.73 | <0.01 | 0.17 | 11 | 0.33 | 2 | FADD |
11q13.3 | 69.90 | <0.01 | 0.16 | 8 | 0.31 | 1 | PPFIA1 |
11q14.1 | 77.01 | 0.38 | 0.12 | 8 | 0.24 | 3 | CLNS1A, INT4 |
11q14.1 | 77.47 | 0.16 | 0.12 | 10 | 0.29 | 3 | NDUFC2*, ALG8*, USP35* |
16p13.2-16p13.13 | 8.78 | 1.68 | 0.38 | 3 | 0.06 | 0 | ABAT, PMM2, USP7 |
16p12.3 | 18.44 | 1.21 | 0.39 | 3 | 0.10 | 0 | NOMO2, ARL6IP, MIR16 |
17q12 | 33.73 | <0.01 | 0.16 | 9 | 0.08 | 3 | MRPL45 |
17q12 | 34.15 | 0.02 | 0.19 | 15 | 0.12 | 4 | PSMB3 |
17q12 | 34.19 | 0.02 | 0.19 | 15 | 0.12 | 4 | CCDC49 |
17q12 | 34.33 | 0.01 | 0.20 | 16 | 0.12 | 4 | LASP1 |
17q12 | 34.67 | 0.01 | 0.23 | 23 | 0.12 | 4 | FBXL20 |
17q12 | 35.06 | 0.02 | 0.27 | 25 | 0.29 | 11 | STARD3, TCAP, PNMT |
17q12 | 35.08 | 0.06 | 0.27 | 27 | 0.29 | 12 | ERBB2, GRB7 |
17q12 | 35.29 | 0.03 | 0.23 | 21 | 0.27 | 10 | GSDML |
17q21.1 | 35.44 | 0.07 | 0.16 | 15 | 0.16 | 5 | THRAP4, NR1D1 |
17q21.2 | 35.77 | 0.03 | 0.13 | 6 | 0.06 | 1 | TOP2A |
17q21.32 | 44.27 | 0.1 | 0.17 | 9 | 0.22 | 3 | ATP5G1, UBE2Z |
17q21.33 | 44.95 | 0.19 | 0.18 | 6 | 0.18 | 2 | SPOP, SLC35B1 |
17q21.33 | 45.80 | 0.02 | 0.19 | 7 | 0.20 | 2 | MRPL27, LRRC59 |
17q22 | 54.12 | 0.44 | 0.19 | 6 | 0.20 | 2 | RAD51C, TRIM37 |
17q23.1 | 55.12 | 0.01 | 0.23 | 9 | 0.20 | 2 | CLTC, PTRH2 |
17q23.1 | 55.38 | 0.1 | 0.23 | 8 | 0.20 | 3 | RPS6KB1, ABC1 |
17q23.3 | 58.97 | 0.29 | 0.23 | 6 | 0.20 | 1 | CCDC44, DDX42, FTSJ3 |
17q24.2 | 62.77 | <0.01 | 0.24 | 7 | 0.33 | 1 | PSMD12 |
17q25.1 | 68.72 | 0.03 | 0.22 | 4 | 0.18 | 0 | COG1, C17orf80 |
17q25.1 | 70.52 | 0.03 | 0.17 | 5 | 0.16 | 0 | ICT1, ATP5H |
17q25.1 | 70.57 | 0.2 | 0.16 | 5 | 0.16 | 0 | HN1, NUP85, MRPS7 |
17q25.1 | 71.15 | 0.15 | 0.17 | 4 | 0.16 | 0 | ITGB4, H3F3B |
20p11.23 | 17.97 | 1.51 | 0.25 | 3 | 0.16 | 0 | ZNF133, RBBP9, HARS2 |
20q13.12 | 42.95 | 0.05 | 0.27 | 2 | 0.29 | 2 | YWHAB |
20q13.12 | 43.77 | 0.2 | 0.26 | 1 | 0.29 | 0 | DNTTIP1, UBE2C, NEURL2 |
20q13.13 | 46.43 | 0.86 | 0.28 | 2 | 0.29 | 1 | CSE1L, STAU1 |
20q13.33 | 60.21 | 0.53 | 0.28 | 3 | 0.31 | 0 | HRH3, ADRM1, LAMA5 |
20q13.33 | 61.45 | 0.2 | 0.27 | 3 | 0.18 | 0 | EEF1A2, C20orf149, PTK6 |
20q13.33 | 62.04 | 0.17 | 0.27 | 3 | 0.20 | 1 | UCKL1, C20orf14, OPRL1 |
21q22.3 | 42.85 | 0.47 | 0.13 | 2 | 0.08 | 0 | SLC37A1, WDR4, NDUFV3 |
21q22.3 | 46.49 | 0.2 | 0.12 | 2 | 0.06 | 0 | MCM3AP |