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Table 1 Summary clinical table

From: High-resolution aCGH and expression profiling identifies a novel genomic subtype of ER negative breast cancer

 

NCH (n = 171)

CAL (n = 145)

p

Sorlie (n = 85)

p

Porter (n = 44)

p

ER+

113 (66%)

96 (66%)

 

56 (76%)

 

29 (66%)

 

ER-

57 (34%)

49 (34%)

1

18 (24%)

0.176

15 (34%)

1

Grade

       

I

41 (24%)

16 (11%)

 

9 (12%)

 

12 (27%)

 

II

57 (34%)

56 (40%)

 

33 (44%)

 

23 (52%)

 

III

72 (42%)

69 (49%)

0.014

33 (44%)

0.063

9 (20%)

0.016

LN+

51 (30%)

74 (51%)

 

53 (70%)

 

11 (28%)

 

LN-

120 (70%)

71 (49%)

0.0001

23 (30%)

<10-8

25 (62%)

1

Age

58 (57.1)

53 (55.4)

0.075

57 (57.8)

0.692

61 (59.5)

0.07

Size (cm)

1.8 (1.9)

2.2 (2.4)

0.0003

NA

 

2 (2.4)

0.67

≤ 1

12 (7%)

8 (6%)

 

NA

 

9 (22%)

 

> 1, ≤ 2

109 (64%)

64 (45%)

 

NA

 

14 (34%)

 

> 2, ≤ 5

49 (29%)

65 (46%)

 

NA

 

13 (32%)

 

> 5

0 (0%)

5 (3%)

0.003

NA

 

5 (11%)

< 10-6

NPI

4.3 (3.9)

4.5 (4.7)

< 10-7

NA

 

NA

 

< 3

34 (20%)

8 (6%)

 

NA

 

NA

 

> 3, < 4

43 (25%)

22 (16%)

 

NA

 

NA

 

> 4, < 5

65 (38%)

50 (36%)

 

NA

 

NA

 

> 5

28 (16%)

58 (42%)

< 10-6

NA

 

NA

 

Therapy

       

None

79 (47%)

16 (11%)

 

0 (0%)

 

NA

 

HT or CT

89 (53%)

128 (89%)

< 10-11

85 (100%)

< 10-16

NA

 
  1. A comparison is provided between the most important clinical parameters of the breast cancer cohort analysed in this study ('NCH') and three additional breast cancer cohorts 'CAL' [6], 'Sorlie' [12] and 'Porter' [11]. For estrogen receptor status (ER), Grade, lymph node status (LN) and Therapy received (HT = hormone therapy, CT = chemotherapy), p values were computed using Fisher's exact test. For age, tumor size and the NPI (Nottingham Prognostic Index) we give the median (and mean) values and the p values obtained using a Wilcoxon rank sum test. For tumor size and NPI we also give the distributions across various thresholds and the corresponding χ2 test p values.