Figure 6

Genes required for miRNA biogenesis are differentially expressed according to molecular subtype and ER status. Shown are boxplots of Illumina log₂ intensities for (a) AGO2 (EIF2C2), (b) DICER1, (c) DROSHA (RNASEN). Data are based on 58 samples that could be classified according to molecular subtype (17 basal-like (red), 5 HER2+ (pink), 18 luminal A (dark blue), 8 luminal B (light blue), 10 normal-like (green)) and 99 samples with known ER status (31 ER- (blue), 68 ER+ (yellow)). (d) Boxplots of mean miRNA expression after control-based normalization. Data are based on 51 samples that could be classified according to molecular subtype (16 basal-like (red), 5 HER2+ (pink), 15 luminal A (dark blue), 9 luminal B (light blue), 6 normal-like (green)) and 93 samples with known ER status (33 ER- (blue), 60 ER+ (yellow)). Black bars indicate the median; boxes interquartile range; whiskers most extreme data points not exceeding 1.5 times the interquartile range; points outliers. P values are based on non-parametric Kruskal-Wallis tests for subtype and Wilcoxon rank sum tests for ER status.