Figure 4
The Candida albicans proteome has a statistical nature. (a) In C. albicans, 33% of the genes do not have CUG codons and 57% have between one and five codons. (b) Ambiguous CUG decoding results in exponential expansion of the proteome, allowing the 6,438 C. albicans genes to generate 2.8379 × 1011 different proteins. (c) The impact of various leucine mis-incorporation levels on the probability of synthesis of proteins with 0, 1, 2, or 3 leucines at CUG positions, for genes containing three CUGs. (d) Number of novel proteins generated through ambiguous CUG decoding in the experimental conditions tested. The total number of novel proteins within a cell was estimated as being of 6.7 × 106 in cells grown at 30°C, of 8.7 × 106 at 37°C, of 10.9 × 106 at pH 4.0, of 9.0 × 106 in the presence of hydrogen peroxide (H2O2), and of 40 × 106 in the highly ambiguous cells. 0.01% indicates background decoding error.