Clustering of genes into regulons using integrated modeling-COGRIM

Table 5 Linear model parameters

Parameter	Details
Baseline gene i expression	α_i ~ Normal(0, $τ_{α}^{2}$ )
TF linear effects	β = (β₁, ..., β_J) ~ MultivariateNormal(0,I· $τ_{β}^{2}$ )
TF interaction effects	γ = (γ₁₂, ..., γ_JK) ~ MultivariateNormal(0,I· $τ_{γ}^{2}$ )
Residual gene expression variance	σ² ~ Inv- $χ_{2}^{2}$ (inverse Chi-square)
Prior distribution weights	w_j~ Uniform(0,1)

ISSN: 1474-760X