Enrichment of MIPS functional annotations. The hypergeometric distribution was used to calculate P values to determine the enrichment of MIPS functional categories, and P values smaller than 0.001 were considered to indicate significant over-represention. For each of the 39 TFs analyzed, (a) the number of significantly over-represented MIPS categories in the functional targets (B+/C+ [red] and B-/C+ [yellow] clusters) and nonfunctional targets (B+/C- cluster [blue]) are summarized. (b) The percentage of genes categorized into significantly over-represented MIPS categories in B+/C+ (red) and B-/C+(yellow) clusters and B+/C- set (blue). TF, transcription factor.