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Table 2 Expression of GABA and JAK signaling-related genes in brain of COX knockout mice

From: Differential gene expression patterns in cyclooxygenase-1 and cyclooxygenase-2 deficient mouse brain

Gene name Region COX-1-/- COX-2-/-
GAT3 Cerebral cortex -42% (-1.86) +66% (+1.68)
GABRB1 Cerebral cortex - -28% (ND)
GABRB1 Hippocampus - -46% (-2.32)
JAK 1 Hippocampus +96% (+1.56) -
JAK 2 Hippocampus - -18% (-2.09)
  1. Percentage change in expression, as validated by Q-PCR, is provided, along with microarray-determined z ratios (in parenthesis) for each genotype comparison. Janus kinase (JAK)1 and 2 expression are altered only in hippocampus of COX-1-/- and COX-2-/- mice. COX, cyclooxygenase; GABA, γ-aminobutyric acid; GABRB1, GABA-A receptor subunit β1; GAT, GABA transporter; ND, not differentially expressed in microarray analysis.