Differential gene expression patterns in cyclooxygenase-1 and cyclooxygenase-2 deficient mouse brain

Table 2 Expression of GABA and JAK signaling-related genes in brain of COX knockout mice

Gene name	Region	COX-1^-/-	COX-2^-/-
GAT3	Cerebral cortex	-42% (-1.86)	+66% (+1.68)
GABRB1	Cerebral cortex	-	-28% (ND)
GABRB1	Hippocampus	-	-46% (-2.32)
JAK 1	Hippocampus	+96% (+1.56)	-
JAK 2	Hippocampus	-	-18% (-2.09)

Percentage change in expression, as validated by Q-PCR, is provided, along with microarray-determined z ratios (in parenthesis) for each genotype comparison. Janus kinase (JAK)1 and 2 expression are altered only in hippocampus of COX-1^-/- and COX-2^-/- mice. COX, cyclooxygenase; GABA, γ-aminobutyric acid; GABRB1, GABA-A receptor subunit β₁; GAT, GABA transporter; ND, not differentially expressed in microarray analysis.

ISSN: 1474-760X