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Figure 1 | Genome Biology

Figure 1

From: Differential gene expression patterns in cyclooxygenase-1 and cyclooxygenase-2 deficient mouse brain

Figure 1

β Oxidation gene expression is increased in cerebral cortex of cyclo-oxygenase (COX)-2-/- mice. The expression of three tandem genes involved in the metabolism of short chain fatty acids to citrate is increased in cerebral cortex of COX-2-/- mice, as determined by microarray and quantitative PCR (Q-PCR) analysis. These genes, namely hydroxyacyl coenzyme-A dehydrogenase (HADH2), acetyl coenzyme-A acetyltransferase (ACAT1) and ATP citrate lyase, are depicted in the ovals above, along with the enzyme classification (EC) number in parenthesis. Z ratio from the microarray analysis and Q-PCR validation results for each gene are provided below the name of the gene. A positive z ratio represents an increase in expression in COX knockout mice, whereas a negative value denotes a decrease in expression in COX knockout mice. Q-PCR percentage represents the percentage increase in expression over wild-type mice. HADH2 and ACAT1 are expressed in the mitochondria and ATP citrate lyase is expressed in the cytosol. The expression of genes represented as a square is not changed.

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