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Table 5 High quality candidates for D2mit490-linked defective thymic deletion

From: Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling

Gene Probeset Group Distance (cM) Fold change Function
5730494N06Rik 1452773_at 6 4.2 1.6 Unknown
Smox 1424268_at 1, 3 4.6 2.9 Oxidizes spermine to spermidine [67], resulting in DNA damage and apoptosis [68]
Bcl2l11/Bim 1456006_at 1426334_a_at 1 6.7 2.3 3.0 Pro-apoptotic initiator for cytokine deprivation [70] and TCR-stimulation of thymocytes [71]
Id1 1425895_a_at 1 8.8 2.2 Inhibits function of E2A and HEB, increases response to TCR stimulation, increases sensitivity to thymocyte apoptosis [72]
Pdrg1 1428309_s_at 3 8.8 1.9 Upregulated by UV radiation and downregulated by p53 [74]
Sqrdl 1420641_a_at 3 10.1 3.9 Disulfide oxidoreductase activity
B2 m 1427511_at 3 10.5 2.7 Component of MHC class I
Acss2 1422479_at 3 10.4 1.7 Oxidation of acetate for acetyl-CoA production (utilized mainly for oxidation) [93]
Pdia3 1423423_at 3 11.0 3.4 Chaperone in the ER lumen, required for mitomycin C-induced cell death [73]
C79248 1442744_at 6 11.0 2.6 Unknown
  1442745_x_at    3.1  
  1446148_x_at    20.5  
  1446147_at    11.3  
Zfp106 1425331_at 3 11.5 1.5 Interacts with FYN and Grb-2 [94]
Tmem87a 1424454_at 6 11.6 6.0 Unknown
Vps39 1451720_at 6 11.6 2.0 Promotes lysosome clustering and fusion in vivo, downstream of rab7 [95]
Inoc1 1418125_at 3 12.2 1.6 Unknown
Ivd 1449001_at 3 12.5 1.8 Isovaleryl coenzyme A dehydrogenase
Scg5 1423150_at 5 15.6 5.6 Neuroendocrine secretory protein [96]
Rcn1 1417090_at 1 20.9 2.1 ER Ca++ binding protein [97]
LOC626832 1436462_at 6 22.8 1.9 Unknown
Polr3k 1422753_a_at 1 26.8 1.6 RNA polymerase
  1. ER, endoplasmic reticulum. Fyn, fyn proto-oncogene. Grb, growth factor receptor binding protein. HEB, transcription factor 12.