Table 5 High quality candidates for D2mit490-linked defective thymic deletion
Gene | Probeset | Group | Distance (cM) | Fold change | Function |
|---|---|---|---|---|---|
5730494N06Rik | 1452773_at | 6 | 4.2 | 1.6 | Unknown |
Smox | 1424268_at | 1, 3 | 4.6 | 2.9 | Oxidizes spermine to spermidine [67], resulting in DNA damage and apoptosis [68] |
Bcl2l11/Bim | 1456006_at 1426334_a_at | 1 | 6.7 | 2.3 3.0 | Pro-apoptotic initiator for cytokine deprivation [70] and TCR-stimulation of thymocytes [71] |
Id1 | 1425895_a_at | 1 | 8.8 | 2.2 | Inhibits function of E2A and HEB, increases response to TCR stimulation, increases sensitivity to thymocyte apoptosis [72] |
Pdrg1 | 1428309_s_at | 3 | 8.8 | 1.9 | Upregulated by UV radiation and downregulated by p53 [74] |
Sqrdl | 1420641_a_at | 3 | 10.1 | 3.9 | Disulfide oxidoreductase activity |
B2 m | 1427511_at | 3 | 10.5 | 2.7 | Component of MHC class I |
Acss2 | 1422479_at | 3 | 10.4 | 1.7 | Oxidation of acetate for acetyl-CoA production (utilized mainly for oxidation) [93] |
Pdia3 | 1423423_at | 3 | 11.0 | 3.4 | Chaperone in the ER lumen, required for mitomycin C-induced cell death [73] |
C79248 | 1442744_at | 6 | 11.0 | 2.6 | Unknown |
| Â | 1442745_x_at | Â | Â | 3.1 | Â |
| Â | 1446148_x_at | Â | Â | 20.5 | Â |
| Â | 1446147_at | Â | Â | 11.3 | Â |
Zfp106 | 1425331_at | 3 | 11.5 | 1.5 | Interacts with FYN and Grb-2 [94] |
Tmem87a | 1424454_at | 6 | 11.6 | 6.0 | Unknown |
Vps39 | 1451720_at | 6 | 11.6 | 2.0 | Promotes lysosome clustering and fusion in vivo, downstream of rab7 [95] |
Inoc1 | 1418125_at | 3 | 12.2 | 1.6 | Unknown |
Ivd | 1449001_at | 3 | 12.5 | 1.8 | Isovaleryl coenzyme A dehydrogenase |
Scg5 | 1423150_at | 5 | 15.6 | 5.6 | Neuroendocrine secretory protein [96] |
Rcn1 | 1417090_at | 1 | 20.9 | 2.1 | ER Ca++ binding protein [97] |
LOC626832 | 1436462_at | 6 | 22.8 | 1.9 | Unknown |
Polr3k | 1422753_a_at | 1 | 26.8 | 1.6 | RNA polymerase |