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Table 3 High quality candidates for the D7mit101-linked allele

From: Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling

Gene

Probeset

Group

Distance (cM)

Fold change

Function

Tnrcba

1439246_x_a

5

6.2

1.3

Unknown

Bnip3

1422470_at

6

8.4

2.0

Vital for CD47-induced apoptosis [59], activation induced apoptosis [62], hypoxic apoptosis [61]

Swap70

1423543_at

1

9.8

3.1

Part of Ig recombination complex [87], Rac-GEF required for membrane ruffling [88]

Rab6ip1

1424015_at

6

10.0

1.8

Interacts with Rab6 [89] (Golgi-ER transport)

1500003O22Rik

1416559_at

3

12.4

1.9

unknown

Trim30

1417961_a_at

3

13.2

3.6

RING, B-box type 1 and 2, coiled coil domains [64]

Trim12

1437432_a_at

3

13.3

297

RING, B-box type 1 and 2, coiled coil domains [64]

Frag1

1424615_at

3

14.6

2.5

Potently activates fibroblast growth factor receptor [90]

LOC675851

1416366_at

3

17.8

3.1

Unknown

Hdgfrp3

1435977_at

3

19.6

2.1

Unknown

  1. ER, endoplasmic reticulum. GEF, guanine nucleotide exchange factor.