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Figure 2 | Genome Biology

Figure 2

From: Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling

Figure 2

Patterns of gene expression changes induced by positive and negative selection in the B10k and NODk strains. Analysis of Affymetrix GeneChip data segregated those probesets that were significantly changed upon positive and/or negative selection (p < 0.005) into patterns A to F based on logical sets of significant contrasts (p < 0.05), where patterns are defined by the relative expression during pre-selection (PreS, left), positive selection (S+, middle) and negative selection (S-, right). The number of probesets falling into each pattern in B10k and NODk mice is listed on the expression pattern. Assignment of probesets to patterns was based only on direction of change, thus the graphical depictions do not represent the degree of change.

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