Conservation profiles of a representative region, the SREBF1 locus, using close (primate) and distant (human-mouse) species comparisons. (a) Seven-primate (human, baboon, colobus, marmoset, dusky titi, owl monkey, and squirrel monkey), (b) human-mouse, and (c) three-primate (human, rhesus, and marmoset) conservation profiles in the SREBF1 locus with flanking genes partially shown. Sequence conservation was calculated using Gumby and visualized using RankVISTA with the human sequence as reference. Vertical bars above the horizontal axis depict evolutionarily conserved sequences, with height indicating the conservation score (-log(conservation p value); see Materials and methods). Coding exons (dark blue) and untranslated regions (UTRs; magenta) are marked below the horizontal axis. Vertical bars that overlap coding exons or UTRs are colored light blue, while non-overlapping bars are colored red. The arrowhead denotes SREBF1_PS, a non-coding element conserved in primates (p value ≤ 0.005) but not in the mouse (p value > 0.1).