Skip to main content

Table 2 GO analysis: normal neuroblasts compared to neuroblastomas

From: Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes

GO

P value

n

GO description

More highly expressed in neuroblast compared to neuroblastoma

GO:0008202

1.33E-18

17

Steroid metabolism

GO:0006694

3.22E-15

12

Steroid biosynthesis

GO:0044255

2.13E-12

18

Cellular lipid metabolism

GO:0008610

8.54E-12

13

Lipid biosynthesis

GO:0016125

1.29E-11

10

Sterol metabolism

GO:0006629

1.50E-10

18

Lipid metabolism

GO:0008203

5.85E-09

8

Cholesterol metabolism

GO:0008207

1.37E-08

5

C21-steroid hormone metabolism

GO:0006700

1.37E-08

5

C21-steroid hormone biosynthesis

GO:0006066

1.55E-08

12

Alcohol metabolism

GO:0042446

9.26E-07

5

Hormone biosynthesis

GO:0016126

1.16E-06

5

Sterol biosynthesis

GO:0042445

9.57E-06

5

Hormone metabolism

GO:0006118

1.76E-05

9

Electron transport

GO:0006869

1.84E-05

5

Lipid transport

GO:0009058

4.62E-05

16

Biosynthesis

GO:0006695

5.39E-04

3

Cholesterol biosynthesis

GO:0042423

6.50E-04

2

Catecholamine biosynthesis

GO:0006810

2.29E-03

20

Transport

GO:0006091

2.32E-03

9

Generation of precursor metabolites and energy

GO:0006584

2.85E-03

2

Catecholamine metabolism

GO:0051234

2.88E-03

20

Establishment of localization

GO:0051179

3.04E-03

20

Localization

GO:0018958

3.46E-03

2

Phenol metabolism

GO:0042401

5.64E-03

2

Biogenic amine biosynthesis

GO:0042398

8.30E-03

2

Amino acid derivative biosynthesis

More highly expressed in neuroblastoma compared to neuroblast

GO:0019882

4.54E-14

16

Antigen presentation

GO:0030333

2.51E-12

14

Antigen processing

GO:0019884

1.21E-08

8

Antigen presentation, exogenous antigen

GO:0019886

3.45E-08

8

Antigen processing, exogenous antigen via MHC class II

GO:0019883

4.23E-07

7

Antigen presentation, endogenous antigen

GO:0006260

2.07E-06

20

DNA replication

GO:0006955

2.45E-06

58

Immune response

GO:0006952

1.02E-05

60

Defense response

GO:0019885

1.03E-05

6

Antigen processing, endogenous antigen via MHC class I

GO:0009607

1.05E-05

66

Response to biotic stimulus

GO:0006270

9.25E-05

6

DNA replication initiation

GO:0006259

4.34E-04

35

DNA metabolism

GO:0009596

5.51E-04

4

Detection of pest, pathogen or parasite

GO:0006261

7.72E-04

10

DNA-dependent DNA replication

GO:0050896

1.03E-03

92

Response to stimulus

GO:0006913

1.42E-03

12

Nucleocytoplasmic transport

GO:0007051

1.84E-03

5

Spindle organization and biogenesis

GO:0016070

2.01E-03

25

RNA metabolism

GO:0007052

2.27E-03

4

Mitotic spindle organization and biogenesis

GO:0009595

2.27E-03

4

Detection of biotic stimulus

GO:0007017

2.67E-03

11

Microtubule-based process

GO:0006658

3.08E-03

2

Phosphatidylserine metabolism

GO:0009613

3.39E-03

34

Response to pest, pathogen or parasite

GO:0006928

3.94E-03

18

Cell motility

GO:0040011

3.94E-03

18

Locomotion

GO:0043207

4.72E-03

34

Response to external biotic stimulus

GO:0007626

5.10E-03

18

Locomotory behavior

GO:0016043

5.31E-03

46

Cell organization and biogenesis

GO:0016049

6.09E-03

12

Cell growth

GO:0008361

6.09E-03

12

Regulation of cell size

GO:0042254

6.39E-03

6

Ribosome biogenesis and assembly

GO:0051169

8.15E-03

10

Nuclear transport

GO:0016071

8.34E-03

16

Mrna metabolism

GO:0043241

8.91E-03

2

Protein complex disassembly

GO:0031498

8.91E-03

2

Chromatin disassembly

GO:0006337

8.91E-03

2

Nucleosome disassembly

GO:0006104

8.91E-03

2

Succinyl-coa metabolism

GO:0007610

9.44E-03

21

Behavior

GO:0007049

9.50E-03

39

Cell cycle

  1. Shown are over-represented GO classes (biological process) (with P < 0.01 and at least two genes) in the list of genes that are more highly expressed in normal neuroblasts than in neuroblastomas, and vice versa. GO, Gene Ontology.