Figure 7
From: Transcriptional and structural impact of TATA-initiation site spacing in mammalian core promoters
Non-optimal TATA-TSS spacing is compensated for by increased signal strength in the TSS region. The signal strength around the initiation site [-5,+5] (measured as information content in bits [45]) is lowest in promoters that have the most favored TATA-TSS spacings (30 and 31 bp). The signal strength is increased in promoters with a TATA-TSS spacing ranging from 32 to 34 bp. This increase is due to an extended initiation site motif, as shown in corresponding sequence logos in Figure 6. bp, base pairs; TSS, transcription start site. bp, base pairs; TSS, transcription start site.