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Figure 3 | Genome Biology

Figure 3

From: Transcriptional and structural impact of TATA-initiation site spacing in mammalian core promoters

Figure 3

The spacing between TATA box and the dominant TSS is associated with transcriptional specificity. (a) Tissue specificity (measured as median relative entropy) for promoters with different TATA-TSS spacing. Positions with 20 counts or more are shown as red dots with standard error bars. (b) Histogram showing number of promoters with the TATA box located at a given position. In both plots, only the most prominent TATA box is considered in each promoter. Both representations indicate that most functional TATA boxes reside in a narrow 4 bp window from positions -32 to -29, dominated by positions -31 and -30. The rapid decrease in site counts and transcriptional specificity downstream of -29 suggests that 28 bp is the minimal TATA-TSS distance for TATA-driven initiation; it might also have functional properties distinct from more favorable spacings (see main text). bp, base pair; TSS, transcription start site.

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