Figure 10

Exploration of SP-class promoters with twin-TSS. (a-d) Sequence logo representations of promoters with two close, dominant peaks separated by 0-3 bp. In contrast to previous sequence logos, we applied no constraint on TATA presence for promoter inclusion. Black arrows denote the location of the two dominant TSSs. The +1 position is arbitrarily defined as the position of the TSS located the furthest upstream. When there is no spacing between the peaks, promoters are depleted of TATA boxes. This type of promoter has an atypical initiation site consensus closely resembling that of transcripts in 3' untranslated region promoters [8]. More diverged peaks have a higher amount of TATA-like motifs around position -30 with respect to the most upstream peak. bp, base pairs; TSS, transcription start site.