Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution

Table 5 Molecular functions of C. elegans duplicate gene pairs with synthetic phenotypes

Duplicate gene pair	NCBI KOGs
pab-1 + pab-2	Polyadenylate-binding protein (RRM superfamily)
rpl-25.2 + rpl-25.1	60s ribosomal protein L23
ptr-2 + ptr-10	Predicted membrane protein (patched superfamily)
unc-78 + tag-216	WD40 repeat stress protein/actin interacting protein
rab-8 + rab-10	GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins
B0495.2 + ZC504.3	Protein kinase PITSLRE and related kinases
rpa-2 + C37A2.7	60S acidic ribosomal protein P2
C28H8.4 + erd-2	ER lumen protein retaining receptor
lin-12 + glp-1	Member of the Notch/LIN-12/glp-1 transmembrane receptor family^a
C13G3.3 + W08G11.4	Serine/threonine protein phosphatase 2A, regulatory subunit
lin-53 + rba-1	Nucleosome remodeling factor, subunit CAF1/NURF55/MSI1
Y53C12A.4 + R02E12.2	Conserved protein Mo25
F37C12.7 + acs-17	Acyl-CoA synthetase
C05G5.4 + F23H11.3	Succinyl-CoA synthetase, alpha subunit
elt-6 + egl-18	GATA-4/5/6 transcription factors
dsh-1 + dsh-2	Dishevelled 3 and related proteins

NCBI eukaryotic orthologous groups (KOGs) [37] are listed for duplicate gene pairs with synthetic phenotypic effects upon combinatorial RNA interference (RNAi). ^aNote that WormBase gene descriptions are used for the duplicate gene pair lin-12 + glp-1.

ISSN: 1474-760X