Table 1 Accession numbers, chromosomal locations, and functions of PGRPs

Insects

Anopheles gambiae, mosquito (Ag)

PGRP-LA

XM_314105

1274911

2L

-

-

PGRP-LB

XM_321943

1281956

2R

-

Predicted amidase

PGRP-LC1

XM_314103

1274909

2L

-

-

PGRP-LC2

XM_558599

1274909

2L

-

-

PGRP-LC3

XM_558600

1274909

2L

-

-

PGRP-S1

XM_310547

1271702

X

-

-

PGRP-S2

XM_557000

3290146

2L

-

-

PGRP-S3

XM_316359

1276947

2L

-

Predicted amidase

PGRP-SC2

XM_316360

1276948

2L

-

Predicted amidase

Apis mellifera, honey bee (Am)

PGRP-L

XM_392452

408924

LG7

-

-

PGRP-S

XM_395941

412484

LG13

-

Predicted amidase

Bombyx mori, domestic silkworm (Bm)

BTL-LP1

AB017519

-

-

-

Predicted amidase

BTL-LP2

AB017520

-

-

-

-

PGRP

AF441723

-

-

-

-

PGRP-S

AB016249

-

-

-

PPO activation [36]

Calpodes ethlius, Brazilian skipper butterfly (Ce)

PGRP-S

AF035445

-

-

-

-

Drosophila melanogaster, fruit fly (Dm)

PGRP-LA-C

NM_206306

39062

3L 67A7

-

-

PGRP-LA-D(a)

NM_206305

39062

3L 67A7

-

-

PGRP-LA-E

NM_206304

39062

3L 67A7

-

-

PGRP-LA-F(b)

NM_206307

39062

3L 67A7

-

-

PGRP-LB-A

NM_141822

41379

3R 86E8

1OHT

Amidase [7,40]

PGRP-LB-B

NM_169393

41379

3R 86E8

-

Predicted amidase

PGRP-LB-C

NM_169392

41379

3R 86E8

-

Predicted amidase

PGRP-LC-A(x)

NM_168324

39063

3L 67A8

2F2L

Imd activation [19,25,29-34], phagocytosis [31]

PGRP-LC-B(a)

NM_140041

39063

3L 67A8

1Z6I, 2F2L

Imd activation [19,29-34]

PGRP-LC-C(y)

NM_206308

39063

3L 67A8

-

Imd activation [33]

PGRP-LD-A

NM_001031942

3771920

3L 67A8

-

-

PGRP-LE

NM_132850

32534

X 13F1

2CB3

Imd and PPO activation [35]

PGRP-LF

NM_140042

39064

3L 67A8-67A9

-

-

PGRP-SA

NM_132499

32099

X 10C6

1SXR, 1S2J

Toll activation [8], carboxypeptidase [12], phagocytosis [24]

PGRP-SB1

NM_140660

39870

3L 73C1

-

Predicted amidase

PGRP-SB2

NM_140659

39869

3L 73C1

-

Predicted amidase

PGRP-SC1a^¶

NM_136563

35859

2R 44E2

-

Amidase [14], Toll activation [24], phagocytosis [24]

PGRP-SC1b^¶

NM_136565

35861

2R 44E2

-

Amidase [14]

PGRP-SC2

AJ55662

-

2R 44E2

-

Predicted amidase

PGRP-SD

AJ556628

-

3L 66A8

-

Toll activation [23]

Glossina morsitans, tsetse fly (Glm)

PGRP-LB

DQ307160

-

-

-

Predicted amidase

PGRP-LC

DQ307161

-

-

-

-

Galleria mellonella, greater wax moth (Gm)

PGRP-A

AF394583

-

-

-

-

PGRP-B

AF394587

-

-

-

-

Holotrichia diomphalia, beetle (Hd)

PGRP-1

AB115774

-

-

-

PPO activation [38]

PGRP-2

AB115775

-

-

-

-

PGRP-3

AB115776

-

-

-

-

Manduca sexta, tobacco hornworm (Ms)

PGRP-1A

AF413068

-

-

-

-

PGRP-1B

AF413061

-

-

-

-

Tenebrio molitor, yellow mealworm (Tm)

PGRP-SA

AB219970

-

-

-

PPO activation [37]

Trichoplusia ni, cabbage looper (Tn)

PGRP-S

AF076481

-

-

-

-

Mollusks

Argopecten irradians, bay scallop (Ai)

PGRP

AY437875

-

-

-

Predicted amidase

Euprymna scolopes, Hawaiian bobtail squid (Es)

PGRP-1

AY956811

-

-

-

Predicted amidase

PGRP-2

AY956812

-

-

-

Predicted amidase

PGRP-3

AY956813

-

-

-

Predicted amidase

PGRP-4

AY956814

-

-

-

-

Echinoderms

Asterias rubens, European starfish (Ar)

PGRP-S1a

DQ222477

-

-

-

Predicted amidase

PGRP-S2a

DQ222478

-

-

-

Predicted amidase

Strongylocentrotus purpuratus, purple sea urchin (Sp)

PGRP-S

XM_781925

581948

-

-

Predicted amidase

Fish

Danio rerio, zebrafish (Dr)

PGLYRP-2

DQ447202

568634

8

-

Predicted amidase

PGLYRP-5

DQ447203

553387

18

-

Predicted amidase

PGLYRP-6

DQ447204

571817

-

-

Predicted amidase

Tetraodon nigroviridis, spotted green pufferfish (Ten)

PGLYRP-2

CAG06114

-

-

-

Predicted amidase

Amphibians

Xenopus laevis, African clawed frog (Xl)

PGLYRP-5

BC087429

496035

-

-

Predicted amidase

Xenopus tropicalis, Western clawed frog (Xt)

PGLYRP-1

NM_001030455

595014

-

-

Predicted amidase

PGLYRP-5

NM_001015775

548492

-

-

Predicted amidase

Birds

Gallus gallus, chicken (Gg)

PGLYRP-2

AY740510

-

-

-

Predicted amidase

Mammals

Bos taurus, cow (Bt)

PGLYRP-1

NM_174573

282305

18

-

Bactericidal [46,47]

PGLYRP-2

XM_588006

510803

7

-

Predicted amidase

PGLYRP-3

XM_611696

532575

3

-

Predicted bactericidal^¥

Camelus dromedaries, camel (Cd)

PGLYRP-1

AJ409286

-

-

-

Predicted bactericidal

Canis familiaris, dog (Cf)

PGLYRP-1

XM_849945

612209

1

-

Predicted bactericidal

PGLYRP-2

XM_847906

610405

20

-

Predicted amidase

Homo sapiens, human (Hs)

PGLYRP-1

NM_005091

8993

19q13.2-q13.3

1YCK

Bactericidal [17]

PGLYRP-2

NM_052890

114770

19p13.12

-

Amidase [9,16]

PGLYRP-3

NM_052891

114771

1q21

1SK3, 1SK4, 1TWQ, 2APH

Bactericidal [17]

PGLYRP-4

NM_020393

57115

1q21

-

Bactericidal [17]

Mus musculus, mouse (Mm)

PGLYRP-1

NM_009402

21946

7 A3

-

Antibacterial [45,48]

PGLYRP-2

AY282722

57757

17

-

Amidase [15]

PGLYRP-3

NM_207247

242100

3 F1

-

Predicted bactericidal

PGLYRP-4

NM_207263

384997

3 F1

-

Predicted bactericidal

Pan troglodytes, chimpanzee (Pt)

PGLYRP-2

XM_512455

455797

19

-

Predicted amidase

Rattus norvegicus, rat (Rn)

PGLYRP-1

NM_053373

84387

1q21

-

Predicted bactericidal

PGLYRP-2

BC088306

299567

7q11

-

Predicted amidase

PGLYRP-3

XM_57498

499658

2q34

-

Predicted bactericidal

PGLYRP-4

XM_227383

310611

2q34

-

Predicted bactericidal

Sus scrofa, pig (Ss)

PGLYRP-1

NM_001001260

397213

-

-

Predicted bactericidal

PGLYRP-2A

AF541955

-

-

-

Amidase [44]

PGLYRP-2B

AF541956

-

-

-

Amidase [44]