Figure 5

Multiple alignment of JAB domain containing proteins. Coloring is indicative of 80% consensus. The coloring scheme, consensus abbreviations and secondary structure representations are as described in the legend to Figure 2. The secondary structure, shown on the first line of the alignment, is derived from a JAB crystal structure whose primary sequence is found on the second line of the alignment, with PDB identifier shaded in gold. Conserved histidine and acidic residues (ED) are colored yellow and shaded in red. The conserved active site serine residue is colored light gray and shaded in teal. The conserved cysteine found in a subset of JABs (marked with an asterisk) are shaded blue and colored white. The alignment is grouped according to families, with family names listed to the right. Also provided are references to the appropriate row on Table 1, which describes a particular JAB containing operon.