Figure 4

Combining information from replicate experiments. (a) Distribution of Fisher p values for NCPs, obtained by taking the product of channel-specific p values and comparing it to the product of random numbers drawn from a uniform distribution (see [28]). The solid line corresponds to probe signal intensities that were first corrected for probe sequence bias using the Full Position-specific model (see Materials and methods); the dashed line corresponds to uncorrected intensities. (b) Distribution of the negative log of products of single-channel p values for different probe populations.