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Figure 3 | Genome Biology

Figure 3

From: Shuffling of cis-regulatory elements is a pervasive feature of the vertebrate lineage

Figure 3

Examples of loci containing shuffled conserved elements. (a) The Sema6d (sema domain, transmembrane domain, and cytoplasmic domain, semaphorin 6D; MGI:2387661) locus contains a post-genic moved-reversed conserved element. The SCE is found downstream from the gene in mammalian loci and upstream of the gene in fish genomes, and in reverse orientation only in the genomes of fugu and tetraodon. (b) the Ptprg (protein tyrosine phosphatase, receptor type G; MGI:97814) locus contains an intronic moved-reversed conserved element. The SCE is found in the first intron of the Ptprg gene in mammalian genomes, downstream of the gene in reverse orientation in fugu and tetraodon, and in the second intron in reverse orientation in zebrafish. Boxes represent the multiple alignments of the SCEs identified. SCE, shuffled conserved region.

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