Table 2 Genes differentially expressed in human CD4⁺CD25⁺ regulatory vs CD4⁺CD25^- naive T cells

NINJ2

Ninjurin 2

ACTN1

Actinin, alpha 1

SLE, CHA

NELL2

NEL-like 2

ITGB2

Integrin, β₂

UC, MC, COPD, T2D, AS, LAD-1, RA, ALPS, SLE

TIAF1

TGFB1-induced antiapoptotic factor 1

TP53INP1

Tumor protein p53 inducible nuclear protein 1

TRAF1 ^a

TNF receptor-associated factor 1

LGALS1

Galectin 1

JIA, RA, IBD

LGALS3 ^a

Galectin 3

RA, JIA

GZMA

Granzyme A

T1D, RA, SLE, IBD

GZMK

Granzyme K

PTTG1

Pituitary tumor-transforming 1

Diabetes

TRIB1

Tribbles homolog 1

S100A10

S100 calcium binding protein A10

CEB1

Hect domain and RLD 5

SLAMF1

Signaling lymphocytic activation molecule family member 1

SLE, X-linked XLP, RA, MS

S100A4

S100 calcium binding protein A4

RA

PIM1

Pim-1 oncogene

ID2

Inhibitor of DNA binding 2

Diabetes

FHIT

Fragile hisT1Dine triad gene

RBMS1

RNA binding motif, single stranded interacting protein 1

IFITM1

Interferon induced transmembrane protein 1

IL2RA ^a

Interleukin 2 receptor, alpha

T1D, profound cellular immunodefiency

TNFRSF1B ^a

Tumor necrosis factor receptor superfamily, member 1B

MC, UC, MS, SLE

CCR5

Chemokine (C-C motif) receptor 5

MS, Grave's disease, RA

GPR2

Chemokine (C-C motif) receptor 10

Autoimmune skin diseases

IL2RB

Interleukin 2 receptor, beta

ITP, RA, osteoarthritis, hemolytic anemia

G1P2

Interferon, alpha-inducible protein

IL1RL2

Interleukin 1 receptor-like 2

IL7R

Interleukin 7 receptor

SCID, RA, SLE

CCR7 ^a

Chemokine (C-C motif) receptor 7

Diabetes, SLE, MS, RA, JIA

TNFSF5

CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome)

HIGM1, Alzheimer disease, T1D, SLE, MS, AS, ITP

CCL5

Chemokine (C-C motif) ligand 5

EAT, MS, diabetes, SLE, RA

TNFRSF10B

Tumor necrosis factor receptor superfamily, member 10b

MS, RA

SDC4

Syndecan 4

CTLA4 ^a

Cytotoxic T-lymphocyte-associated protein 4

T1D, Grave's disease, SLE

TFRC

Transferrin receptor

AKAP2

A kinase (PRKA) anchor protein 2

DGKA

Diacylglycerol kinase, alpha

PITPNC1

PhosphaT1Dylinositol transfer protein, cytoplasmic 1

TRGV9

T cell receptor gamma variable 9

CD81

CD81 antigen

PECAM1

Platelet/endothelial cell adhesion molecule

ITP, diabetes, AS, RA, CIA, MS

FOXP3

Forkhead box P3

IPEX, T1D

GATA3

GATA binding protein 3

RA, HDR syndrome

BHLHB2

Basic helix-loop-helix domain containing, class B, 2

SLE

SATB1

Special AT-rich sequence binding protein 1

STAT4

Signal transducer and activator of transcription 4

MC, EAE, UC, diabetes, COPD, SLE, arthritis

STAT6

Signal transducer and activator of transcription 6

EAE, RA, autoimmune uveitis, diabetes

MYC

v-myc Myelocytomatosis viral oncogene homolog

Diabetes, RA, SLE

TCF7

Transcription factor 7 (T-cell specific, HMG-box)

T1D

XBP1

X-box binding protein 1

T2D, RA

CNOT2

CCR4-NOT transcription complex, subunit 2

HLA-DMA

Major histocompatibility complex, class II, DM alpha

T1D, SLE, RA

HLA-DRB1

Major histocompatibility complex, class II, DR beta 1

RA, MS, sarcoidosis, Sjögren's syndrome, Grave's disease, T1D

HLA-DRB3

Major histocompatibility complex, class II, DR beta 3

SLE, RA, MS, sarcoidosis, Sjögren's syndrome, Grave's disease

GBP2

Guanylate binding protein 2, interferon-inducible

GBP5

Guanylate binding protein 5

SLC40A1 (a)

Solute carrier family 40 (iron-regulated transporter), member 1

SHMT2 (b)

Serine hydroxymethyltransferase 2 (mitochondrial)

EPSTI1

Epithelial stromal interaction 1

NOSIP

Nitric oxide synthase interacting protein