The Heterochromatin Protein 1 family

Table 1 Examples of HP-1 interacting partners

Protein	Hp-1 variant	Domain	References
Transcriptional regulators or chromatin-modifying proteins
Histone H1	HP1	ND	[57]
Histone H3	HP1, HP1^Mmα, HP1^Mmβ, HP1^Mmγ	CD	[57,58]
Methyl K9 Histone H3	Swi6, HP1, HP1α, HP1β, HP1γ	CD	[15,16,18]
Histone H4	HP1, HP1^Mmα	CSD	[51,58]
SUV39H1	HP1, HP1α, HP1β, HP1γ	CSD	[59]>
Polycomb	HP1^Hsα, HP1^Hsγ	CSD	[38,60]
Dnmt3a	HP1^Mmα	ND	[42,61]
Dnmt3b	HP1α, HP1β	ND	[61]
Kap-1/Tif1β	HP1α, HP1β, HP1γ	CSD	[25,62,63]
Rb	HP1^Hsγ	ND	[37]
MITR	HP1^Mmα	Linker	[64]
BRG1	HP1^Mmα	CSD	[65]
ATRx	HP1^Mmα, HP1^Mmβ	CSD	[66]
TAF_II130	HP1^Hsα, HP1^Hsγ	CSD	[67]
PIM1	HP1^Hsγ	CSD	[30]
RNA	HP1^Mmα, HP1^Mmγ	Linker	[68]
DNA replication and repair proteins
CAF-1p150	HP1α, HP1β	CSD	[69]
Ku70	HP1^Hsα, phosphoS83-HP1^Hsγ	CSD, Linker	[27,49]
ORC1-6	HP1	CD, CSD	[70]
Other chromosome-associated proteins
Psc3	Swi6	CD	[71]
INCENP	HP1^Hsα, HP1^Hsγ	Linker	[72]
Hsk1/CDC7	Swi6	ND	[73]
Ki-67	HP1^Mmα, HP1^Mmβ, HP1^Mmγ	CSD	[74]
SP100	HP1^Hsα, HP1^Hsβ, HP1^Hsγ	CSD	[75]
Nuclear structure proteins
Nuclear envelope	HP1^Mmα, HP1^Mmβ, HP1^Mmγ	CD	[36]
Lamin B receptor	HP1^Hsα, HP1^Hsβ, HP1^Hsγ	CSD	[35,58]
Lamin B	HP1^Mmβ	CD	[36]
LAP2β	HP1^Mmβ	CD	[36]

Domain abbreviations: CD, chromodomain; CSD, chromoshadow domain; ND, not determined. Protein abbreviations: ATRx, alpha thalassemia/mental retardation syndrome; BRG1, SWI/SNF related transcriptional activator; CAF-1p150, chromatin assembly factor-1 p150 subunit; Dnmt3a/Dnmt3b, deoxyribonucleic acid (DNA) methyltransferase 3a and 3b; 'HP1' alone refers to Drosophila HP1; HP1α, HP1β and HP1γ refer to both mouse and human unless specified (Mm, mouse; Hs, human); Hsk1/CDC7, S. pombe homolog of CDC7, cell division cycle 7; INCENP, inner centromere protein; Kap-1/Tif1β, Kruppel-associated box (KRAB)-associated protein/transcriptional intermediary factor 1β; Ki-67, cell prliferation antigen of monoclonal antibody Ki-67; Ku70, 70K autoantigen; LAP2β, lamina-associated polypeptide 2β; MITR, myocyte enhancer factor 2 (MEF2)-interacting transcription repressor; ORC1-6, origin recognition complex 1-6; PIM1, proviral integration site 1 (pim-1) oncogene; Psc3, cohesion subunit Psc3; Rb, retinoblastoma protein; RNA, ribonucleic acid; SP100, nuclear autoantigenSpeckled 100 kD; Swi6 refers to the S. pombe HP1 ortholog Swi6; SUV39H1, Histone H3 lysine 9-selective methyltransferase; TAF_II130, TATA-binding protein associated factor p130.

ISSN: 1474-760X