The MAP1 family of microtubule-associated proteins

Table 2 Interaction partners of MAP1-family proteins

	Interacting protein*	Proposed function of the interaction	References
MAP1A	Microtubules	Stabilization of microtubules	[14,13,17]
	F-actin	Integration of microtubule and F-actin cytoskeletons	[13]
	EPAC	Enhancement of Rap1 GTPase activity and cell adhesion	[42]
	DISC1	Linking of DISC1 to microtubules; pathogenesis of schizophrenia	[43]
	PSD-93	Linking of PSD-93 to microtubules	[44]
	CK1δ	Interaction with and phosphorylation of the MAP1A light chain LC2 in vitro	[45]
	BKCa potassium channel	Association of the channel with the cytoskeleton	[46]
MAP1B	Microtubules	Stabilization of microtubules	[13,15,16,47]
	F-actin	Integration of microtubule and F-actin cytoskeletons	[13,18,48]
	Mapmodulin	Modulation of neurite extension	[49]
	Gigaxonin	Enhanced stabilization of microtubules by MAP1B; control of MAP1B light chain degradation; potential role in giant axonal neuropathy	[37,50]
	Myelin-associated glycoprotein	Enhanced MAP1B expression and phosphorylation	[51]
	GABA(C) receptor	Linking of GABA(C) receptors to the cytoskeleton	[52]
	FMR1	Interaction with MAP1B mRNA and repression of its translation	[53]
	ee3	Alteration of the stability or folding of ee3	[54]
	LIS1	Interference with the LIS1-dynein interaction	[55]
	GRIP1	Localization of AMPA receptors to synaptic sites	[56]
LC3	Microtubules	Regulation of the microtubule binding of MAP1A and MAP1B	[6]
	Caldendrin	Transduction of calcium signals	[57]
MAP1S	Microtubules	Stabilization of microtubules	[4]
	F-actin	Integration of microtubule and F-actin cytoskeletons	[4]
	RASSF1A	Regulation of mitotic progression	[58,59]

*Abbreviations: EPAC, exchange protein directly activated by cAMP; DISC1, disrupted-in-schizophrenia 1; PSD-93, postsynaptic density-93; CK1δ, casein kinase I delta; BKCa, large-conductance Ca²⁺-dependent K⁺ channel; GABA, gamma-aminobutyric acid; FMR1, Fragile X mental retardation 1; ee3, orphan G-protein coupled receptor; LIS1, lissencephaly-related protein 1; AMPA, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; GRIP1, glutamate receptor interacting protein 1; RASSF1A, Ras association domain family 1A.

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