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Figure 3 | Genome Biology

Figure 3

From: The elusive yeast interactome

Figure 3

The two TAP studies yield dramatically different protein complexes. (a) Comparison of the composition of most similar complexes from Gavin et al. [1] and Krogan et al. [2]. Each circle represents a comparison of a complex from [1] to its most similar counterpart (that is, the complex that shares most of its proteins) in the dataset of [2]. The size of the complex is plotted along the x-axis and the percentage overlap in composition with the complex from [2] is plotted along the y-axis. The diamonds represent the same exercise carried out for complexes from [2] compared with their most similar counterparts from [1]. As an example, complex 219 (solid black circle) is 60% identical to complex 285 (solid black circle), whereas complex 285 has a 100% overlap with 219 (Figure 2). As each symbol refers to a one-way comparison, symbols may be superimposed but usually refer to different complexes/comparisons. (b) The pie-chart on the left shows the overlap between the 491 complexes identified in Gavin et al. [1], including cores, modules and attachments, and the 547 complexes from Krogan et al. [2], whereas the pie-chart on the right presents the converse analysis. For example, from the right-hand chart, there are 77 complexes reported in [2] that each have 50-90% of their proteins contained in a complex reported in [1]. In the left-hand chart, complex 219 from [1], with an overlap of 60% with complex 285 from [2] would be one of the 46 complexes in the slice showing the overlap range 50-90%. Conversely, complex 285 is one of the 48 complexes from [2] that overlap >90% with one of the complexes from [1], in this case complex 219. More details, such as which complexes are related to which, are available at [21].

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