Table 2 Amino acid substitutions in polymorphic variants
From: Mutation patterns of amino acid tandem repeats in the human proteome
Substitutions within repeats | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
From/to | A | E | G | L | P | S | K | Q | V | I | M | F | W | T | C | Y | N | D | R | H | Total |
A | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 5 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 9 |
E | 0 | 0 | 4 | 0 | 0 | 0 | 8 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 21 |
G | 2 | 2 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 3 | 0 | 13 |
L | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
P | 7 | 0 | 0 | 1 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7 | 0 | 0 | 0 | 0 | 2 | 1 | 20 |
S | 0 | 0 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 9 |
K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4 |
Q | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 |
Total | 9 | 2 | 8 | 1 | 3 | 8 | 8 | 6 | 6 | 0 | 0 | 3 | 0 | 9 | 2 | 0 | 1 | 5 | 6 | 2 | 79 |
Rel. frequency | 0.11 | 0.03 | 0.10 | 0.01 | 0.04 | 0.10 | 0.10 | 0.08 | 0.08 | 0.00 | 0.00 | 0.04 | 0.00 | 0.11 | 0.03 | 0.00 | 0.01 | 0.06 | 0.08 | 0.03 | |
Substitutions in repeat adjacent sequences* | |||||||||||||||||||||
A | 0 | 0 | 6 | 0 | 4 | 3 | 0 | 0 | 5 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 21 |
E | 0 | 0 | 1 | 0 | 0 | 0 | 5 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 13 |
G | 6 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 7 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 1 | 5 | 0 | 26 |
L | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 4 | 0 | 4 | 1 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 15 |
P | 8 | 0 | 0 | 2 | 0 | 6 | 0 | 3 | 0 | 1 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 1 | 24 |
S | 0 | 0 | 2 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 13 |
K | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 3 | 0 | 1 | 0 | 11 |
Q | 0 | 1 | 0 | 3 | 1 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 3 | 12 |
Total | 14 | 6 | 9 | 7 | 7 | 13 | 7 | 7 | 17 | 2 | 4 | 6 | 2 | 6 | 4 | 0 | 3 | 7 | 10 | 4 | 135 |
Rel. frequency | 0.10 | 0.04 | 0.07 | 0.05 | 0.05 | 0.10 | 0.05 | 0.05 | 0.13 | 0.01 | 0.03 | 0.04 | 0.01 | 0.04 | 0.03 | 0.00 | 0.02 | 0.05 | 0.07 | 0.03 |