Figure 9

Co-occurrence of WW domains and WW domain binding sites. (a) Positions of the WW domains (green bars) and conserved primary sequence motifs (PPxY/F in red, LPxY/F in blue) in Wwm1, Rsp5, Alg9 and Ssm4. (b) Radial trees and motif conservation for the ortholog groups of each protein. Organism abbreviations are Saccharomyces cerevisiae (Sc),Candida guilliermondii (Cgui),Candida glabrata (Cgla),Chaetomium globosum (Cglo),Kluyveromyces waltii (Kw),Kluyveromyces lactis (Kl),Yarrowia lipolytica (Yl),Candida lusitaniae (Cl),Debaryomyces hansenii (Dh),Schizosaccharomyces pombe (Sp),Pneumocystis carinii (Pc),Fusarium graminearum (Fg),Magnaporthe grisea (Mg),Neurospora crassa (Nc),Podospora anserina (Pa),Aspergillus fumigatus (Af),Aspergillus nidulans (An),Ashbya gosypii (Ag),Histoplasma capsulatum (Hc),Coccidioides immitis (Ci), Ustilago maydis (Um),Cryptococcus neoformans (Cn),Coprinus cinereus (Cc),and Rhizopus oryzae (Ro). Solid branches indicate lineages in which the WW domain is present; dashed lines indicate the absence of a WW domain. Colored branches indicate lineage in which a motif is present; lineages in gray lack the motif. The histograms represent the relative conservation of S. cerevisiae motifs of the form X-X-x-X among the orthologs. Red and blue dots indicate the bins that contain the highlighted motifs.